Το Δι-Ιδρυματικό Μεταπτυχιακό Πρόγραμμα Σπουδών
(ΔΠΜΣ Τμήματος Χημείας και Ινστιτούτου Βιοεπιστημών & Εφαρμογών ΕΚΕΦΕ “Δημόκριτος”)
Εφαρμοσμένη Βιοχημεία:
Κλινική Χημεία, Βιοτεχνολογία & Αξιολόγηση Φαρμακευτικών Προϊόντων
στο πλαίσιο του
"Κύκλου σεμιναρίων προσκεκλημένων ομιλητών"
που διοργανώνει
την Τετάρτη 22 Δεκεμβρίου 2021 και ώρα 13:00
σας προσκαλεί στη διαδικτυακή διάλεξη του
Prof. Martin Götte
Münster University Hospital, Münster, Germany
με θέμα:
Role of Cell Surface Heparan Sulfate Proteoglycans in Cancer and Inflammation
σε σύνδεση μέσω zoom:
https://upatras-gr.zoom.us/j/5583501511?pwd=M2cyNjdWMFdQeEFjSVpsb1NZWDgzQT09
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Announcement - Invitation
The Postgraduate Program
(Joint Postgraduate Programme of the Department of Chemistry and the Institute of Biosciences and Applications of NCSR "Demokritos”)
Applied Biochemistry:
Clinical Chemistry, Biotechnology & Evaluation of Pharmaceutical Products
in the context of
"Seminars of invited speakers"
invites you to his online lecture on
Wednesday, December 22, 2021 at 13:00
Prof. Martin Götte
Münster University Hospital, Münster, Germany
on the subject:
Role of Cell Surface Heparan Sulfate Proteoglycans in Cancer and Inflammation
online zoom:
https://upatras-gr.zoom.us/j/5583501511?pwd=M2cyNjdWMFdQeEFjSVpsb1NZWDgzQT09
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Short cv: Martin Götte is a Professor at the Department of Gynecology and Obstetrics of the University of Münster, Germany. He obtained his diploma (Biology) in 1994 at the University of Münster, and his Ph.D. (Biochemistry) in 1997 from the University of Göttingen and the Max-Planck-Institute for Biophysical Chemistry. After postdoctoral research at the Department of Cell Biology of Harvard Medical School, Boston, USA, he obtained a tenured position as head of the research laboratory of the Department of Gynecology and Obstetrics of Münster University Hospital. His main areas of research are the role of syndecans, decorin, and glycosaminoglycan biosynthetic enzymes in cancer and inflammation.
Short talk description: The malignant behavior of cancer cells is determined not only by cell-autonomous factors but also by a permissive microenvironment. The extracellular matrix (ECM) plays a major role in either supporting or inhibiting tumor cell behavior. Epigenetic mechanisms and a dysregulated endocrine milieu favor altered ECM synthesis. Aberrant production and function of cell surface proteoglycans conveys signals to tumor which promote metastatic behavior, unlimited tumor growth, and cancer stem cell function linked to therapeutic resistance and relapse. Proteoglycans mediate matrix-dependent signaling events via growth factors and chemokines, modulating angiogenesis and immune cell function in the tumor microenvironment. Moreover, they regulate the function of immune cells, shifting their function from an anti-cancerous to a permissive state. Focusing on the function of the cell surface proteoglycan family of syndecans, this lecture will provide basic knowledge on the function of these proteoglycans in signal transduction, matrix adhesion and degradation, and in regulating inflammatory processes and angiogenesis in the context of tumor progression.
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Prof. Nikos Karamanos
