Professor

Tel: (+302610) 996029

e-mail:

Web Page: http://www.chem.upatras.gr/faculty/theocharis

List of Publications:

• Google Scholar

• Scopus

Contact hours: Monday & Wednesday 10:00-12:00

Curriculum Vitae

Education, degrees & scientific carrier

1994 Diploma in Chemistry, Department of Chemistry, University of Patras.

1995 Visiting scientist, Department of Experimental Medical Sciences, Lund University.

1999 Visiting scientist, Karolinska Institute, Department of Immunology, Microbiology, Pathology and Infectious diseases.

2000 Ph.D. in Biochemistry, Department of Chemistry, University of Patras.

2000-2002 Post-doctoral researcher, Department of Chemistry, University of Patras.

2002-2003 Post-doctoral researcher, Karolinska Institute, Department of Immunology, Microbiology, Pathology and Infectious diseases.

2003-2008 Lecturer, Department of Chemistry, University of Patras.

2008-2014 Assistant Professor of Biochemistry & Molecular Biology, University of Patras.

2008-2009 Visiting Professor, Ludwig Institute for Cancer Research, Uppsala University, Sweden.

2012 Visiting Professor, Laboratory CRRET, University Paris 12 (UPEC), Paris, France.

2014-2019 Associate Professor of Biochemistry & Molecular Biology, University of Patras.

2019- Professor of Biochemistry & Molecular Biology, University of Patras.

Indicators of Research Activity

• 115 Publications in peer-review journals
• 8950 Citations (Scopus, June 2024)
• 12700 Citations (Google Scholar, June 2024)
• h-index= 47 (Scopus, June 2024)
• h-index= 54 (Google Scholar, June 2024)
• 115 International Conference Publications
• 60 National Conference Publications
• 26 Invited Lectures

Honors & Awards

Fellowship of Hellenic Scholarship Foundation (1995-1999).

Fellowship from University of Lund, Department of Cell and Molecular Biology, Section for Connective Tissue Biology (1996).

Fellowship from Karolinska Institute, Department of IMPI (1999).

Award from Leonidas Zervas Foundation (1999).

Award from Hellenic Society of Biochemistry and Molecular Biology (2000).

Post-doctoral Fellowship of Hellenic Scholarship Foundation (2002).

Fellowship from Federation of European Biochemical Societies (2002).

Fellowship from Federation of European Biochemical Societies (2008).

A number of awards have been conferred by various Scientific Societies, among them the Biochemical & Molecular Biology Society, Society for Anticancer Research, Federation of European Connective Tissue Societies, etc.

Research proposal evaluator

Evaluation of Research Proposals in French National Research Agency (2022).

Evaluation of Research Proposals in "The American University of Beirut - Collaborative Research Stimulus (CRS) grants" Lebanon (2015).

Evaluation of Research Proposals in National Research, Development and Innovation Office, Hungary, (NKFIH) (2014).

Reviewer in peer-review journals: Nature Communications, Nature Reviews Urology, FEBS Journal, BBA Reviews on Cancer, Matrix Biology, Matrix Biology Plus, Frontiers in Cell and Developmental Biology, Molecules, Biomolecules, International Journal of Molecular Sciences, Pharmacology & Therapeutics, Molecular Biology reports, Archives Biochemistry and Biophysics, Advanced Drug Delivery Reviews, The Journal of Biological Chemistry, Osteoarthritis and Cartilage, Mechanisms of Ageing and Development, European Journal of Cell Biology, Gene, PlosOne, Inflammation Research, Connective Tissue Research, Andrology, BMC Cancer, BBA-General Subjects, BBA-Molecular Cell Research, Breast Cancer Research, Biomed Research International, Experimental Cell Research, Experimental Gerontology, Cogent Biology, Journal of Histochemistry & Cytochemistry, Bioscience Reports, Journal of Cellular and Molecular Medicine, Journal of Experimental & Clinical Cancer Research, Veterinary Pathology, Journal of Physiology and Biochemistry, Frontiers in Oncology, Biomaterials, Journal of Biomedical Science, Cell and Tissue Research, Seminars in Cancer Biology, etc).

Editorial board: American Journal of Physiology – Cell physiology, Biomolecules, Molecular Biology Reports, Matrix Biology, Matrix Biology Plus, Cancers

Associate Editor: Frontiers in Cell and Developmental Biology

Guest Editor: Special Issue: "Cellular Microenvironment in Human Pathologies" in BioMed Research International.

Book editor: "The Extracellular Matrix: Methods and Protocols In Series "Methods in Μolecular Biology" Springer Science (2018) D. Vigetti, A.D. Theocharis (eds).

Book Section Editor: In Extracellular Matrix: Pathobiology and Signaling, edited by N. Karamanos, DeGruyter 2012.

Organization of workshops, meetings/symposia

• European Training Program in Microseparation Techniques (ECOSEP 1). An environmental imperative on microscale analytical techniques Patras, Greece (1998).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Patras, Greece (2007).
• 2th Congress of Biosciences in University of Patras, Patras, Greece (2007).
• 33rd FEBS Congress - 11th IUBMB Conference Athens, Greece (2008).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Patras, Greece (2009).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Spetses, Greece (2011).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Kos, Greece (2013).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Rhodes, Greece (2015).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Spetses, Greece (2017).
• FEBS Advanced Lecture Course: Extracellular Matrix: Cell Regulation, Epigenetics and Modeling, September 27th-October 2nd, Patras (2018).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Porto Heli, Greece (2019).
• FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Crete, Greece (2022).
• 72th Congress of Hellenic Society for Biochemistry and Molecular Biology (HSBMB), Patras, Greece (2022).

Trainees: Supervisor / advisor for 9 Ph.D. and 40 M.Sc. students.

Member of the evaluation board for Ph.D. students at the University of Tromso (second opponent: Ph.D. Nabin Malla, Department of Medical Biology, Faculty of Health Sciences, University of Tromso-2011) and University of Oslo (first opponent: Ph.D. Trine Marita Reine, Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo-2013).

Administrative experience

Member of the General Assembly of the Division of Organic Chemistry, Biochemistry and Natural Products at the Department of Chemistry (2004-)

Member of the General Assembly at the Department of Chemistry (2004-)

Head of the Division of Organic Chemistry, Biochemistry and Natural Products at the Department of Chemistry (2019-2020)

Head of the Department of Agriculture, University of Patras (May to August 2019)

Head of the Department of Chemistry, University of Patras (2020-)

Member of the Senate of the University of Patras (2020-)

Member /departmental coordinator of the committee of Erasmus Programme (2004-2019)

Member of the Erasmus Programme Coordination at the University of Patras (2010-2012)

Member of the committee of Hygiene and Safety at the Department of Chemistry (2006-2019)

Member of the Board of Directors at the Company of Exploitation and Management for the Property of the University of Patras (2014-2017)

Member of the Board of Hellenic Society of Biochemistry & Molecular Biology (2020- / 2020-2022, General Secretary / 2024- Vice President)

International Collaborations and Research Networks

University of Paris 12, France (Prof. S. Menashi, E. Huet).

Karolinska Institute, School of Medicine, Sweden (Prof. A. Hjerpe, K. Dobra).

University of Uppsala, Sweden (Prof. C.H. Heldin, A. Moustakas, P. Heldin).

University of Lund, Sweden (Prof. A.M. Blom).

University of Trondheim, Norway (Prof. M. Borset, A. Sundan).

University of Oslo, Norway (Prof. S. Kolset, K. Prydz, H. Tveit).

University of Tromso, Norway (Prof. J.O. Winberg, E. Knutsen).

University of Muenster, Germany (Prof. M. Gotte).

University of Varese, Italy (Prof. A. Passi, D. Vigetti).

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, USA (Prof. RV Iozzo).

Research Project

Principal Investigator/ Co-investigator in 19 International / National Research Projects.

Useful links
Departmental & Personal website: www.chem.upatras.gr/faculty/theocharis
List of Publications: www.publicationslist.org/a.d.theocharis
Research Network: www.biotargeting.upatras.gr
Advanced Lecture Courses: www.febs-mpst2013.upatras.gr, www.febs-mpst2015.upatras.gr

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Courses

Undergraduate: Basic Elements of Biology and Physiology, General Biology, Clinical Chemistry, Biochemistry I, Biochemistry II (laboratory practice).

Graduate (M.Sc. & Ph.D.): Courses M.Sc. & Ph.D.: Cell Biology, Molecular Biology, Molecular Biology & Molecular Biotechnology, Clinical Biochemistry, Analytical Chemistry & Clinical Biochemistry, Advanced Biochemistry, Applied Biochemistry and Biotechnology (laboratory practice), Genetic and Molecular Basis of Diseases- Molecular Medicine.

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Research Activities

Biochemistry, Cell & Molecular Biology with focus on extracellular matrix.
Pathobiology of diseases (Expression and biological role of extracellular matrix in disease development, in cell growth and functions - molecular targeted therapies).
1. Structure, function, immunological and biological properties of carbohydrates, proteoglycans and glycoproteins isolated from invertebrates and vertebrates.
2. Structure and functions of proteoglycans/glycosaminoglycans and proteases in various (patho)physiological conditions, such as human atherosclerosis and abdominal aortic aneurysm and malignant neoplasias (malignant tumors of gastrointestinal track and pancreas, gynecological tumors).
3. Effect of growth factors and drugs in malignant cell growth and its biosynthetic machinery.

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Representative Publications

List of Peer-Reviewed Publications https://www.scopus.com/authid/detail.uri?authorId=7003720000

• Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Advanced Drug Delivery Reviews. Nov 10. pii: S0169-409X(15)00257-4. doi: 10.1016/j.addr.2015.11.001. (2015).
• Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Ralph D S, Schaefer L, Iozzo RV, Karamanos NK. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochimica et Biophysica Acta, Reviews on Cancer. Mar 28;1855(2):276-300 (2015).
• Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK. Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells. Matrix Biology, pii: S0945-053X(15)00045-1. doi: 10.1016/j.matbio.2015.02.008 (2015).
• Korpetinou A, Papachristou DJ, Lampropoulou A, Bouris P, Labropoulou VT, Noulas A, Karamanos NK, Theocharis AD. Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines. Biomed Research International. 2015:690721. doi: 10.1155/2015/690721. (2015).
• Milia-Argeiti E, Mourah S, Vallée B, Huet E, Karamanos NK, Theocharis AD, Menashi S. EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor-stroma interaction. Biochimica et Biophysica Acta, General Subjects, 1840, 2581-8 (2014).
• Theocharis AD, Gialeli C, Bouris P, Giannopoulou E, Skandalis SS, Aletras AJ, Iozzo RV, Karamanos NK. Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer. FEBS J. 2014 Nov;281(22):5023-42.
• Korpetinou A, Skandalis SS, Labropoulou VT, Smirlaki G, Noulas A, Karamanos NK, Theocharis AD. Serglycin: At the Crossroad of Inflammation and Malignancy. Frontiers in Oncology. 2014 Jan 13;3:327. eCollection 2014 Jan 13.
• Korpetinou A, Skandalis SS, Moustakas A, Happonen KE, Tveit H, Prydz K, Labropoulou VT, Giannopoulou E, Kalofonos HP, Blom AM, Karamanos NK, Theocharis AD. Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells. PLoS One, 31;8(10):e78157 (2013).
• Skliris A, Labropoulou VT, Papachristou DJ, Aletras A, Karamanos NK, Theocharis AD. Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases. FEBS J. 280, 2342-52 (2013).
• Dedes PG, Kanakis I, Gialeli Ch, Theocharis AD, Tsegenidis T, Kletsas D, Tzanakakis GN, Karamanos NK. Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease. Biochimica et Biophysica Acta General Subjects, 1830, 3625-34 (2013).