Professor

Tel: (+302610) 996029

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Web Page: http://www.chem.upatras.gr/faculty/theocharis

Curriculum Vitae

Education and Employment
1994: Diploma in Chemistry, Department of Chemistry, University of Patras.
2000: Ph.D in Biochemistry, "Study of proteoglycans in the development of abdominal aortic aneurysm", Department of Chemistry, University of Patras.
2000-2002: Post-doctoral researcher, Department of Chemistry, University of Patras.
2002-2003: Post-doctoral researcher, Karolinska Institute, Department of Immunology, Microbiology, Pathology and Infectious diseases.
2003-2008: Lecturer of Biochemistry & Molecular Biology, Laboratory of Biochemistry, Department of Chemistry, University of Patras.
2008-2014: Assistant Professor of Biochemistry & Molecular Biology, Laboratory of Biochemistry, Department of Chemistry, University of Patras.
2008–2009: Visiting Professor, Ludwig Institute for Cancer Research, Uppsala University, Sweden (Prof. C.H. Heldin).
2012: Visiting Professor, Laboratory CRRET, University Paris 12 (UPEC), Paris, France.
2014- AssociateProfessor of Biochemistry & Molecular Biology, Laboratory of Biochemistry, Department of Chemistry, University of Patras.

International Scientific Conference Organizations
1. European Training Program in Microseparation Techniques (ECOSEP 1). An environmental imperative on microscale analytical techniques (1998).
2. FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets (2007).
3. 33rd FEBS Congress - 11th IUBMB Conference (2008).
4. FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets (2009).
5. FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Spetses, Greece (2011) www.febs-mpst2011.upatras.gr
6. FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Kos, Greece (2013) www.febs-mpst2013.upatras.gr
7. FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Rhodes, Greece (2015) www.febs-mpst2015.upatras.gr

Fellowships - Awards - Honors
1. Graduate fellowship of Hellenic Scholarship Foundation (1995-1999).
2. Fellowship from University of Lund, Department of Cell and Molecular Biology, Section for Connective Tissue Biology (1996).
3. Fellowship from Karolinska Institute, Department of IMPI (1999).
4. Award from Leonidas Zervas Foundation (1999).
5. Award from Hellenic Society of Biochemistry & Molecular Biology (2000).
6. Post-doctoral Fellowship of Hellenic Scholarship Foundation (2002).
7. Fellowship from Federation of European Biochemical Societies (2002).
8. Fellowship from Federation of European Biochemical Societies (2008).
9. Numerous awards in National and International Conferences (Hellenic Society of Biochemistry & Molecular Biology, Society of Anticancer Research, Federation of European Connective Tissue Societies, etc.).

Publications/books/lectures/citations
• 86 publications (Research and Reviews) in international peer review journals.
• 5 Publications as chapters in book series.
• >100 abstracts in proceedings of International and Hellenic scientific conferences.
• 20 invited and plenary lectures in International and Hellenic scientific conferences and International research institutes and universities.
• > 2.200 citations.
• H-index = 26.

Trainees
Supervisor for 5 M.Sc. students and 3 Ph.D. students. 3 Ph.D. and 3 M.Sc. under progress.

Scientific Collaborations and Scientific Networks
International Collaborations:
1. Karolinska Institute, School of Medicine, Sweden (Prof. A. Hjerpe, K. Dobra).
2. University of Uppsala, Sweden (Prof. C.H. Heldin, A. Moustakas, P. Heldin).
3. University of Lund, Sweden (Prof. A.M. Blom, D. Heinegard).
4. University of Trondheim, Norway (Prof. M. Borset, A. Sundan).
5. University of Paris 12, France (Prof. S. Menash, E. Huet).
6. University of Oslo, Norway (Prof. S. Kolset, K. Prydz, H. Tveit).
7. University of Nantes, France (Prof. D. Heymann).
Local Collaborators:
1. University of Patras, School of Medicine (Prof. H. Kalofonos, D. Papachristou).
2. University of Athens, School of Medicine (Prof. E. Terpos).
3. Institute of Biology “Demokritos” (Dr. D. Kletsas).
4. University of Crete, School of Medicine (Prof. G. Tzanakakis, A. Zafiropoulos).
Member of the Scientific Research Network: Biotargeting - Biomedical and Biotechnological Applications Research Network (www.biotargeting.upatras.gr).

Funded Research Projects
Coordinator in 3 National and 1 International research projects. Co-investigator in 2 National research projects.

Funded by MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) [Grant Agreement number: 645756 — GLYCANC — H2020-MSCA-RISE-2014] for the Action: "Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer". Collaborators: WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITA DEGLI STUDI DELL'INSUBRIA, UPPSALA UNIVERSITET, NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS", SEREND-IP GMBH, FIDIA FARMACEUTICI SPA, SEMMELWEIS EGYETEM, CAIRO UNIVERSITY.

Useful links
Departmental & Personal website: www.chem.upatras.gr/faculty/theocharis
List of Publications: www.publicationslist.org/a.d.theocharis
Research Network: www.biotargeting.upatras.gr
Advanced Lecture Courses: www.febs-mpst2013.upatras.gr, www.febs-mpst2015.upatras.gr

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Courses

Undergraduate: Elements of Biology, Clinical Chemistry, Biochemistry I, Biochemistry II (laboratory practice).

Graduate (M.Sc. & Ph.D.): Clinical Biochemistry, Biochemical Analysis & Clinical Biochemistry, Molecular Biology & Molecular Biotechnology, Applications of Biochemistry & Biotechnology (laboratory practise), Cell Biology.

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Research Activities

Biochemistry, Cell & Molecular Biology with focus on extracellular matrix.
Pathobiology of diseases (Expression and biological role of extracellular matrix in disease development, in cell growth and functions - molecular targeted therapies).
1. Structure, function, immunological and biological properties of carbohydrates, proteoglycans and glycoproteins isolated from invertebrates and vertebrates.
2. Structure and functions of proteoglycans/glycosaminoglycans and proteases in various (patho)physiological conditions, such as human atherosclerosis and abdominal aortic aneurysm and malignant neoplasias (malignant tumors of gastrointestinal track and pancreas, gynecological tumors).
3. Effect of growth factors and drugs in malignant cell growth and its biosynthetic machinery.

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Representative Publications

• Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Advanced Drug Delivery Reviews. Nov 10. pii: S0169-409X(15)00257-4. doi: 10.1016/j.addr.2015.11.001. (2015).
• Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Ralph D S, Schaefer L, Iozzo RV, Karamanos NK. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochimica et Biophysica Acta, Reviews on Cancer. Mar 28;1855(2):276-300 (2015).
• Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK. Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells. Matrix Biology, pii: S0945-053X(15)00045-1. doi: 10.1016/j.matbio.2015.02.008 (2015).
• Korpetinou A, Papachristou DJ, Lampropoulou A, Bouris P, Labropoulou VT, Noulas A, Karamanos NK, Theocharis AD. Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines. Biomed Research International. 2015:690721. doi: 10.1155/2015/690721. (2015).
• Milia-Argeiti E, Mourah S, Vallée B, Huet E, Karamanos NK, Theocharis AD, Menashi S. EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor-stroma interaction. Biochimica et Biophysica Acta, General Subjects, 1840, 2581-8 (2014).
• Theocharis AD, Gialeli C, Bouris P, Giannopoulou E, Skandalis SS, Aletras AJ, Iozzo RV, Karamanos NK. Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer. FEBS J. 2014 Nov;281(22):5023-42.
• Korpetinou A, Skandalis SS, Labropoulou VT, Smirlaki G, Noulas A, Karamanos NK, Theocharis AD. Serglycin: At the Crossroad of Inflammation and Malignancy. Frontiers in Oncology. 2014 Jan 13;3:327. eCollection 2014 Jan 13.
• Korpetinou A, Skandalis SS, Moustakas A, Happonen KE, Tveit H, Prydz K, Labropoulou VT, Giannopoulou E, Kalofonos HP, Blom AM, Karamanos NK, Theocharis AD. Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells. PLoS One, 31;8(10):e78157 (2013).
• Skliris A, Labropoulou VT, Papachristou DJ, Aletras A, Karamanos NK, Theocharis AD. Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases. FEBS J. 280, 2342-52 (2013).
• Dedes PG, Kanakis I, Gialeli Ch, Theocharis AD, Tsegenidis T, Kletsas D, Tzanakakis GN, Karamanos NK. Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease. Biochimica et Biophysica Acta General Subjects, 1830, 3625-34 (2013).

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