Professor

e-mail:

Web Page: http://www.chem.upatras.gr/faculty/tsegenidis

List of Publications:

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Curriculum Vitae

Professor of Organic Chemistry & Organic and Biochemical Analysis.

Date and place of birth: 2-9-1954 Thessaloniki/Greece Nationality: Greek

Education

1976 Diploma in Chenistry, Dept. of Chemistry, University of Patras

1979 Ph.D. in Chemistry, Dept. of Chemistry, University of Patras

1992 Post doc Res Fellow, Institute of Molecular Biology, Dept. of Biology, University of Edinburgh

Career/Employment

University of Patras, Dept. of Chemistry: a. Lecture (1981 - 87), b. Assistant Professor (1987 - 92), c. Associate Professor (1992 - 99), d. Professor (1999 - now)

Membership of Professional Societies

• Association of Greek Chemists
• Hellenic Society for Biochemistry & Molecular Biology (HSBMB) & Hellenic Connective tissue Club
• Federation of European Biochemical Societies (FEBS)
• Federation of European Connective Tissue Societies (FECTS)

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Courses

Undergraduate:

• Organic Chemistry
• Chemistry of Organic Natural Products
• Special topics in organic chemistry

Postgraduate:

• Lectures on Organic and Biochemical Analysis

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Research Activities

• Carbohydrates and their derivatives (a. Structure, function, immunological and biological properties of carbohydrates, proteoglycans and glycoproteins from invertebrates and vertebrates. b. Development of high-performance liquid chromatographic methods for chemical and structural analysis of carbohydrates, proteoglycans and glycoproteins)
• Sialic acids and relation with cancer.
• Peptide chemistry (Synthesis, structure, analysis and interactions of peptides and amino acid derivatives)
• Analysis of pesticides (Development of high-performance liquid chromatographic & capillary electrophoretic methods for chemical analysis of pesticidesand toxins).

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Representative Publications

• Oxytocin and Lysine-vasopressin with N5, N5-Dialkylglutamine in the 4 Posistion: Effect of Introducing Sterically Hindered Groups into the Hydrophilic Cluster of NeurchypophysealHormones . G Stahl, C. Smith, R. Walter, T. Tsegenidis, G. Stavropoulos, P. Cordopatis and D. Theodoropoulos J. Med. Chem., 23, 213-217 (1980)
• Darstellung von TritylaminoalkoholenBarlos, D. Papaioannou, S. Patrianakou and T. TsegenidisLiebigs Ann. Chem., 952-955 (1986)
• Determination of Iduronic Acid and Glucuronic Acid in Glycosaminoglycans after Stoichiometric Reduction and Depolymerization Using High - Performance Liquid Chromatography and Ultraviolet Detection. N. K. Karamanos, A. Hjerpe, T. Tsegenidis, B. Engfeldt and C. A. Antonopoulos Anal. Biochem., 172, 410-419 (1988)
• Fmoc - His (Mmt)-OH und Fmoc-His (Mtt)-OH. ZweineueHistidin derivate Nim-geschutztmitsaure-hochempfindlichenGruppen. Darstellung, Eigenschaften und Einsatz in der Peptidsynthese . K. Barlos, O. Chatzi, D. Gatos, G. Stavropoulos und T. Tsegenidis Tetrahedron Letters, 32, 475-478 (1991)
• Purification and characterisation of a minor low sulphatedDermatanSulphate-proteoglycan from Ray skin C. C. Chatziioannidis, N.K. Karamanos, S.T. Anagnostides and T. TsegenidisBiochimie, 81, 187-196 (1999)
• Determination of carbendazim, thiabendazole and o-phenylphenol residues in lemons by HPLC following sample clean-up by ion-pairing K.P. Prousalis, D. A. Polygenis, A. Syrokou, F.N.Lamari, T. Tsegenidis Analytical and Bioanalytical Chemistry. 379, 458-463 (2004)
• Production of antibodies from chicken egg-yolk to Phenyl-N-methylcarbamate insecticides for analytical purposes Konstantinos P. Prousalis, Gerasimos M. Tsivgoulis and Theodore Tsegenidis. International Journal of Environmental and Analytical Chemistry 87, 1065-1078 (2007).
• Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells. C J Malavaki, A E Roussidis, C Gialeli, D Kletsas, T Tsegenidis, A D Theocharis, G N Tzanakakis, N K Karamanos, FEBS J 280, 2477-2489 (2013)
• Synthesis and biological evaluation of new C-10 substituted dithranol pleiotropic hybrids Bariamis, S.E., Magoulas, G.E., Grafanaki, K., Pontiki, E., Tsegenidis, T., Athanassopoulos, C.M., Maroulis, G., Papaioannou, D., Hadjipavlou-Litina, D. Bioorganic and Medicinal Chemistry 23, 7251-7263(2015)