Professor

Tel: (+302610) 997909

e-mail:

Web Page: http://www.soclab.chem.upatras.gr

http://www.chem.upatras.gr/faculty/athanassopoulos

List of Publications:

• Google Scholar

Contact hours: Tuesday 10:00-12:00, Thursday 10:00-12:00

Curriculum Vitae

2021-today: Professor of Organic Chemistry, Department of Chemistry, University of Patras

2016-2021: Associate Professor of Organic Chemistry, Department of Chemistry, University of Patras,

2018 (April 11th to July 25th) : Visiting Professor for Research at  "La Sapienza" - Università di Roma, Italy

2017 (September 11th to October 10th) : Visiting Professor at Universitè Paul Sabatier, Toulouse, France

03/2010-2016: Assistant Professor of Organic Chemistry, Dept. of Chemistry, University of Patras, Greece.

03/2006-03/2010: Lecturer in Organic Chemistry, Dept. of Chemistry, University of Patras, Greece.
2005-2006: Postdoctoral Research Fellow in the Department of Chemistry, University of Patras, Greece. Scholarship by the Greek State Scholarship's Foundation (IKY).

1995-1996 Researcher in the Dept. of Chemistry, University of Calabria, Cosenza, ITALY (12 months, Human Capital And Mobility, EU Fellowship)

1994: Researcher in the Dept. of Chemistry, University of Minho, Braga, PORTUGAL (2 months, Human Capital And Mobility, EU Fellowship).

1991 & 2003: Diploma in Chemistry and Ph.D. in Organic Chemistry by the Dept. of Chemistry, University of Patras, Greece

Professional Societies

American Chemical Society,
Royal Society of Chemistry,
American Society for Mass Spectrometry,
Association of Greek Chemists

Proposal reviewer for

REPRISE/ CINECA, Ministero dell'Istruzione dell'Università e della Ricerca,  ITALY 
Kingdom of Saudi Arabia, Ministry of  Education,  SAUDI ARABIA
General Secretariat for Research and Technology (GSRT), GREECE

FELLOWSHIPS

Human Capital & Mobility EU Fellowships (1994, 1995, 1996).
Scholarship by the Greek State Scholarship's Foundation (IKY) for Postdoctoral Research, 2005.
“Pythagoras II” Program Fellowship for Postdoctoral Reasearch 2005-2006.
YYDRASIL Fellowship from the Research Council of Norway for Postdoctoral Research at the University of Bergen, Norway, 2009

SUMMER SCHOOLS

June 1993 & July 1996: NATO Advanced Study Institute (ASI) on Mass Spectrometry in the Biomolecular Science, Lacco Ameno, Ischia and Altavilla Milicia, Palermo, ITALY respectively.
September 2004: Ischia Advanced School of Organic Chemistry (IASOC 2004), Ischia, ITALY.

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Courses

I)Undergraduated courses

Chemistry of Heterocyclic Compounds and Biomolecules (Dept. of Chemistry, UoP)
Spectroscopy of Organic compounds (Mass Spectrometry, Dept. of Chemistry UoP)
Synthetic Organic Chemistry (Dept. of Chemistry, UoP)
Experimental Organic Chemistry I (Dept. of Chemistry, UoP)
Experimental Organic Chemistry II (Dept. of Chemistry, UoP)

II)Post-Graduated courses

Organic Synthesis of Drugs (MSc Programme 'Medicinal Chemistry and Chemical Biology'; Depts. of Chemistry and Medicine, UoP).
Analysis of bioactive Molecules (MSc Programme 'Medicinal Chemistry and Chemical Biology'; Depts. of Chemistry and Medicine, UoP).
Investigating the Micro- and Nano-World: Microscopy (MSc Programme 'Analytical Chemistry'; -Mass Spectrometry-, Dept. of Chemistry)

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Research Activities

Synthetic Organic and Medicinal Chemistry [main]

His research interests focus on the development of bioactive molecule synthesis methodologies (mainly anticancer, antimalarial and antimicrobial agents). These include:

• Chemical modification of natural products of biological interest e.g. natural di- and tri-terpenes (abietic acid, dehydroabietic acid, carnosic acid, dehydroabiethylamine, betulin, betulinic acid, etc.), polyamines and their conjugates (arachnotoxins Angel416, HO-416b, JSTX-3), artemisinin and its conjugates, retinoids, antibiotics (chloramphenicol, ciprofloxacin, norfloxacin) with the aim of improving their biological profile.
• Synthesis of small organic molecules (hybrids and conjugates) carrying pharmacophore groups that interact with more than one cellular target (HDAC-Proteasome dual inhibitors, D9a-DMNT-HDAC),
• Synthesis of small organic molecules with immunomodulatory activity (which target the PD1/PDL1 axis) and their conjugates with other anticancer agents.

Mass Spectrometry [secondary]

• Synthesis of labeling reagents (heavy/ light) for applications in analysis by Mass Spectrometry.
• Solid Phase Synthesis of “chemical probes” for applications in Mass Spectrometry Proteomics.

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Representative Publications

• Jerónimo Laiolo, Dafni G Graikioti, Cecilia L Barbieri, Mariana B Joray, Antonia I Antoniou, D Mariano A Vera, Constantinos M Athanassopoulos*, María C Carpinella, “Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein” Sci Rep14, 70 (2024). https://doi.org/10.1038/s41598-023-49939-9
• Vamvoukaki, G.; Antoniou, A.I.; Baltas, M.; Mouray, E.; Charneau, S.; Grellier, P.; Athanassopoulos, C.M.* “Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity”Antibiotics2024, 13, 142. https://doi.org/10.3390/antibiotics13020142
• Tsirogianni, A.; Ntinou, N.; Karampatsou, K.; Dinos, G.; Kournoutou, G.G.; Athanassopoulos, C.M.*, “Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and Reduced Toxicity”.Molecules2024, 29, 4169. https://doi.org/10.3390/molecules29174169
• Ferro, A.; Graikioti, D.; Gezer, E.; Athanassopoulos, C.M.*; Cuendet, M. “Entinostat-Bortezomib Hybrids against Multiple Myeloma”Molecules2023, 28, 1456. https://doi.org/10.3390/molecules28031456
• Tsirogianni, A.; Kournoutou, G.G.; Mpogiatzoglou, M.; Dinos, G.; .; Athanassopoulos, C.M.*; “Chloramphenicol Derivatization in Its Primary Hydroxyl Group with Basic Amino Acids Leads to New Pharmacophores with High Antimicrobial Activity”. Antibiotics2023, 12, 832. https://doi.org/10.3390/antibiotics12050832
• Grigoropoulou, S.; Manou, D.; Antoniou, A.I.; Tsirogianni, A.; Siciliano, C.; Theocharis, A.D.; Athanassopoulos, C.M.* “Synthesis and Antiproliferative Activity of Novel Dehydroabietic Acid-Chalcone Hybrids”Molecules2022, 27, 3623. https://doi.org/10.3390/molecules27113623
• Vassileiou, C.; Kalantzi, S.; Vachlioti, E.; Athanassopoulos, C.M.*; Koutsakis, C.; Piperigkou, Z.; Karamanos, N.; Stivarou, T.; Lymberi, P.; Avgoustakis, K.; et al. “New Analogs of Polyamine Toxins from Spiders and Wasps: Liquid Phase Fragment Synthesis and Evaluation of Antiproliferative Activity”.Molecules2022, 27, 447. https://doi.org/10.3390/molecules27020447
• Natalia Pediconi, Francesca Ghirga, Cristina Del Plato, Giovanna Peruzzi, Constantinos M. Athanassopoulos, Mattia Mori, Maria Elisa Crestoni, Davide Corinti, Franco Ugozzoli, Chiara Massera, Alessandro Arcovito, Bruno Botta, Alberto Boffi, Deborah Quaglio, and Paola Baiocco, “Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells” Bioconjugate Chemistry202132 (6), 1105-1116. DOI: 10.1021/acs.bioconjchem.1c00137
• Dionissia A. Pepe, Dimitra Toumpa, Christiane André-Barrès, Christophe Menendez, Elisabeth Mouray, Michel Baltas, Philippe Grellier, Dionissios Papaioannou, and Constantinos M. Athanassopoulos*, “Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity” ACS Medicinal Chemistry Letters 202011 (5), 921-927. DOI: 10.1021/acsmedchemlett.9b00669
• Palla, D.; Antoniou, A.I.; Baltas, M.; Menendez, C.; Grellier, P.; Mouray, E.; Athanassopoulos, C.M.* “Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline”.Molecules2020, 25, 4858. https://doi.org/10.3390/molecules25204858