Professor

Tel: (+302610) 997914

e-mail:

Web Page: http://www.chem.upatras.gr/faculty/vynios

List of publications:

• Google Scholar
• Publicationslist

Contact hours: 12.00-13.00, daily
Contact form: Vynios Demitrios

Curriculum Vitae

1976-1980 Graduate studies in the Department of Chemistry of the University of Patras
1981-1987 Research Assistant, Chair of Biochemistry, Department of Chemistry, University of Patras
1987 Ph.D. in Biochemistry
1988-1993 Lecturer of Biochemistry, Department of Chemistry, University of Patras
October 1988 Post-Graduate Sudies in immunosorbent assays, Hellenic Pasteur Institute, Athens, Greece
1990-1991 Research associate in the Kennedy Institute of Rheumatology, London, UK.
1993-1999 Assistant Professor of Biochemistry, Department of Chemistry, University of Patras
1999-2006 Associate Professor of Biochemistry, Department of Chemistry, University of Patras

2007-today Professor of Biochemistry, Department of Chemistry, University of Patras

Invited Editor
"Mimetic peptides in allergy and inflammation treatment"
D. H. Vynios
Anti-Inflammatory and Anti-allergy Agents in Medicinal Chemistry, January 2009 (www.bentham.org)

"Osteoarthritis and its treatment"
D. H. Vynios
Current Medicinal Chemistry: Anti-Inflammatory and Anti-allergy Agents, June 2005 (www.bentham.org)

Honours and awards

Best poster award for the poster
“The diagnostic significance of collagen type IX and HNK-1 epitope in XFS", M.S. Assouti, C.D. Georgakopoulos, S.P. Gartaganis and D.H. Vynios, presented in XIXth FECTS Meeting, Taormina, Italy, 2004.

Best poster award for the poster
«Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition», K. Karamanou, M. Franchi, Z. Piperigkou, C. Perreau, F.- X. Maquart, D. H. Vynios and S. Brézillon, Presented in 6th FEBS-MPST, Greece, 2017

A figure of the paper "The increased accumulation of structurally modified versican and decorin is related with the progression of laryngeal cancer», SS Skandalis, AD Theocharis, N Papageorgakopoulou, DH Vynios, DA Theocharis, Biochimie, 88, 1135-1143 (2006) has been selected as front cover of the Journal.

Editorial board
Anti-Inflammatory and Anti-allergy Agents in Medicinal Chemistry, since 2006 (www.bentham.org)

World Journal of Gastroenterology, since 2013 (http://www.wjgnet.com)

Molecular and Cellular Oncology, review editor, από το 2023 (https://www.tandfonline.com/journals/kmco20)

Publications/books/lectures

• > 90 publications in peer-reviewed scientific journals / web pages.
  For a detailed list of publications in scientific journals visit: www.publicationslist.org/vynios
• 5 book chapters
• 5 students’ text books
• > 350 abstracts in Panhellenic and International conferences
• > 30 invited lectures in Panhellenic and International conferences / symposia, as well as in Research Institutes and Universities
• 3 invited publications in web pages
• > 3800 citations (Google Scholar) / > 2800 (Scopus/web of sciences)
• H-index = 32 / 29

Trainees
Supervisor for 8 Ph.D. and 43 M.Sc. awarded studies, several PhD and MSc are under progress. For further details see the attachment.

Collaborations and Research Networks

Collaboration at international level with: Research Unit MEDyc, University of Reims (France)

Collaboration at National level with: School of Medicine and Pharmacy (Univ. of Patras), University Hospital (Patras) και School of Mechanical Engineering (Univ. Of Patras).

Participation in the University of Patras Research Network: Biotargeting - Biomedical and Biotechnological Applications Research Network. (http://www.biotargeting.upatras.gr/).

Participation in the University of Patras Research Network: OsteoNet: Network for the Study of Degenerative and Metabolic Diseases of bone and Cartilage. (http://www.osteonet.gr/)

For more information: http://www.biomedexperts.com/Profile.bme/1497763/Demitrios_H_Vynios

Research Projects
Coordination of a number of National research projects

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Courses

Graduate Programme

1. Biochemistry Ι (tutorials)
2. Biochemistry ΙΙ (Laboratory excercises)
3. Biochemistry III (Lectures, Laboratory excercises)
4. Biotechnology (Lectures, Laboratory excercises)
5. Clinical Chemistry (Laboratory excercises)
6. Instrumental Analysis of Biomolecules (Lectures)
7. Microbiology (Lectures, Laboratory excercises)

Post-graduate Programme

1. Biochemical Analysis – Clinical Chemistry
2. Molecular Biology and Molecular Biotechnology

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Research Activities

1. Isolation, macromolecular structure, biochemical characterisation, and immunological properties of proteoglycans and glycosaminoglycans of various organisms, under normal and pathologic conditions  
2. Isolation and characterisation of enzymes of various organisms, under normal and pathologic conditions
3. Development and application of bioanalytical methods
4. Hydroxyapatite formation in vivo and in vitro
5. Macromolecular interactions of extracellular matrix macromolecules
6. Development and application of methods for the detection of proteoglycan autoantibodies in serum
7. Expression of extracellular macromolecules in cell cultures
8. Production of Biofuels from wastes
9. Preparation and examinations of tissue engineering scaffolds

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Representative Publications

Detailed list of publications http://www.biomedexperts.com/Profile.bme/1497763/Demitrios_H_Vynios

• I. Iliakis, E. Iliakis, D. Vynios.
  Towards the optimization of ozone therapy in knee osteoarthritis: Factors influencing treatment outcomes.
  Journal of Orthopedics 2025 May-August; 17(2): Ahead of Print.

• C. Velesiotis, M. Kanellakis, D. H. Vynios.
  Steviol glycosides affect functional properties and macromolecular expression of breast cancer cells.
  IUBMB Life. 2022 Oct;74(10):1012-1028. doi: 10.1002/iub.2669.

• K. Karamanou, M. Franchi, D. H. Vynios, S. Brézillon
  Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator.
  Semin Cancer Biol. 2019 S1044-579X(19)30121-X. doi: 10.1016/j.semcancer.2019.08.003

• C. Velesiotis, S. Vasileiou, D. H. Vynios 
  A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value.
  FEBS J. 2019 Aug;286(15):3057-3074. doi: 10.1111/febs.14860.

• C. Velesiotis, S. Vasileiou, D. H. Vynios 
  Analyzing Hyaluronidases in Biological Fluids.
  Methods Mol Biol. 2019;1952:127-142. doi: 10.1007/978-1-4939-9133-4_12

• K. Karamanou, M. Franchi, Z. Piperigkou, C. Perreau, F. X. Maquart, D. H. Vynios, S. Brézillon
  Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition
  Sci Rep. 2017;7:45138. doi: 10.1038/srep45138

• Z. Piperigkou, K. Karamanou, N.A. Afratis, P. Bouris, C. Gialeli, C.L. Belmiro, M.S. Pavão, D.H. Vynios, A.M. Tsatsakis
  Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules
  Toxicol Lett. 2016;240:32-42. doi: 10.1016/j.toxlet.2015.10.005

• T. Panogeorgou, E. Tserbini, S. Filou, D.H. Vynios, S.S. Naxakis, T.A. Papadas, P.D. Goumas, N.S. Mastronikolis
  Hyaluronan synthases and hyaluronidases in nasal polyps
  Eur Arch Otorhinolaryngol. 2016;273(7):1801-8. doi: 10.1007/s00405-015-3848-6

• S. Filou, A. Korpetinou, D. Kyriakopoulou, D. Bounias, M. Stavropoulos, P. Ravazoula, D. J. Papachristou, A. D. Theocharis, D. H. Vynios
  ADAMTS expression in colorectal cancer
  PLoS One. 2015 Mar 18;10(3):e0121209

• DH Vynios
  Metabolism of cartilage proteoglycans in health and disease.
  Biomed Res Int. 2014;2014:452315. doi: 10.1155/2014/452315 http://www.hindawi.com/journals/bmri/2014/452315/