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Karamanos Nikos

Karamanos N.
Karamanos N.


Tel: (+302610) 997915, 997181

Fax: (+302610) 997153


Web Page :

List of Publications:

Contact hours: Monday 13:00-15:00, Tuesday 09:00-11:00

Curriculum Vitae

Professor of Biochemistry and Organic Biochemical Analysis, Dept. of Chemistry, Univ. of Patras.

Education and degrees
1984 & 1988: Diploma (Chemistry, grade A) and Ph.D. (Biochemistry, grade A), Department of Chemistry, University of Patras
1987-1999: Researcher and Post doc Research Fellow (annual periods, total 3-years) at Karolinska Institute, Dept. of Laboratory Medicine, School of Medicine, Stockholm, Sweden
1990-2002: Lecturer (1990), Assistant Professor (1993), Associate Professor (1999), Dept of Chemistry, University of Patras
2003-present: Professor of Biochemistry & Organic Biochemical Analysis, University of Patras
2004-present: Member of the administrative board of the Hellenic Society of Biochemistry & Molecular Biology (HSBMB) as President (2006-2007), General Secretary (2004-2005 & 2011), Vice-President (2008-2011 & 2014-present)
2003-present: Coordinator of the Hellenic Matrix Biology section of HSBMB (former Hellenic Research Club for Connective Tissue and Matrix Biology) and contact person in the European Matrix Biology Society (former Federation of European Connective Tissue Societies-FECTS)
2007-2009: European Union Expert, FP7, theme “Health”
2010-present: Collaborative Faculty Member of the Institute ICE-HT (FORTH), Patras, Greece
2007-2011: Head of the Department of Chemistry, University of Patras
2011: European Registered Toxicologist (ERT)
2012-present: Member of the Quality Assurance Unit of the University of Patras (MODIP) and president 2014-present
2014-present: Vice-Rector of Academic & International Affairs

Editorial Scientific Boards/Reviewer & Awards:
Member of the editorial boards (Editorial Board member) of several peer-review journals. Among them: Matrix Biology and Matrix Biology Plus (Deputy editor), FEBS Journal (editorial advisory board), PLoS ONE (academic editor), The Journal of Biological Chemistry (2009-2014), Current Medicinal Chemistry, Biomedical Chromatography, Current Pharmaceutical Analysis, Current Chemical Biology, Chromatographia (2004-2009), Data Sets in Biology, Science Open, and several other scientific journals. 
Participation in the editorial boards and action as reviewer in peer review scientific journal (>35) in the areas of Biochemistry, Biochemical & Pharmaceutical Analysis, Cell Biology, Molecular Biology, Anticancer Agents, Oncology, Cancer, Matrix Biology, Cell signaling, Targeted Molecular Therapeutic Approaches, Extracellular Matrix, Drug Pharmacological Evaluation and Cancer.
A number of awards has been conferred by various Scientific Societies, among them the Hellenic Society of Biochemical & Molecular Biology Society, Society for Microbiology and Biopathology, Pediatrics, Society for Anticancer Research, European associated Societies Comet and Leonardo Da Vinci, Neurological Society, Federation of European Connective Tissue Societies, etc. 
Several publications on pharmacological targeting of metalloproteinases and proteoglycans were among the top most-cited publications in FEBS J in 2013 and 2014. According to BiomedExperts and Scholar websites (links are given below) Dr. Karamanos is among the top authors and most cited in the areas: Matrix Biology, Glycosaminoglycans, Proteoglycans and Metalloproteinases.

Quest editor/Editor: 

1. Special Issue (N. Karamanos, guest editor): Matrix Modeling & Remodeling, Matrix Biology (2019)
2. Biology of Extracellular Matrix, International editions of book series (Series Editor, 2018-present), Elsevier
3. Special Issue (N. Karamanos, guest editor): Matrix-mediated cell behavior and properties, Biochimica et Biophysica Acta-General Subject (2014)
4. MiniReview Series (N. Karamanos and A. Passi, coordinators): Novel insights into matrix pathobiology regulatory mechanisms in health and disease , FEBS J, 2014
5. Special Isuue (N. Karamanos and R. Linhardt, coordinators): Proteoglycans signaling, targeting and therapeutics, FEBS J (2013) 280 (10), 2119–2534
6. International Book Edition: Extracellular Matrix: Pathobiology and Signaling (Nikos Karamanos Editor), ISBN 978-3-11-025876-9 (2012), Walter DeGruyter, Berlin/Boston
7. MiniReview Series (V. Hascall and N. Karamanos, coordinators): Regulatory roles of hyaluronan in health and disease, FEBS J, Vol. 278(9) (2011)
8. MiniReview Series (H. Nagase and N. Karamanos, coordinators): Metalloproteinases in Health and Disease: challenges and the future prospects, FEBS J, Vol. 278(1) (2011)
9. MiniReview Series (R. Iozzo and N. Karamanos, coordinators): Proteoglycans in Health and Disease: emerging concepts and future directions, FEBS J, Vol. 277 (2010)
10. Special issue: Matrix Pathobiology, Signaling and Molecular Targets, Conn. Tissue Res. (2008) Vol. 49, issues 2 & 3.
11. Special issue: Solid phase assays for molecules with biopharmaceutical importance, J. Pharm. Biomed. Analysis, Elsevier, Vol. 34 (2004).
12. Special issue: CE of carbohydrates (Analysis of carbohydrate macromolecules by capillary electrophoresis: glycoproteins, proteogycans/glycosaminoglycans and glycolipids), Biomedical Chromatography, Wiley Interscience, Vol. 16 (2002).

Organization of workshops, meetings/symposia, Editorial Boards, Honors and awards
Chairman of the FEBS Advanced lecture Courses (since 2007) in the thematic area: Matrix Pathobiology, Signaling and Molecular Targets (, Chairman of the FEBS ALC on Extracellular Matrix, Cell Regulation and Epigenetics (  Co-chair of the International Conference on Proteoglycans, Seven Lakes-Italy, 2017). Chairman of the 60th Hellenic Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, 2009. Scientific Secretary and International Contact person of the 33rd FEBS Congress-11th IUBMB Conference (2008). Secretary of the 17th FECTS International Conference (2000). Chairman of the Commet EU Training Course on Advanced analytical techniques (1992) and Leonardo Da Vinci EU meeting on Microseparation techniques (1998). Member of the organizing committee of a series of scientific meetings of the Hellenic Connective tissue and Extracellular Matrix section, and of the 1st and 2nd Conference of Biosciences of the University of Patras as well as in a series of international conferences.



  • More than 280 publications (Research and Reviews) in international peer review journals.
  • 1 International book with 54 chapters and 7 thematic sections, Published by DeGruyter, 2012, Berlin/Boston
  • 35 Publications as chapters in book series and full proceeding
  • 3 books on biomolecules structure-function and enzyme immunoassays 
  • More than 250 abstracts in proceedings of International and National scientific conferences
  • More than 100 invited, confirmed and plenary lectures in International meetings/conferences (including FECTS-2004 Italy, FEBS-2010 Sweden, Gordon Research Conference on Proteoglycans-2012, 2014, 2016 USA, International Proteoglycans' conference, 2013 & 2015 Germany and Seoul), Hellenic scientific conferences and International Research Institutes and Universities (including University of Reims and Paris-France, Munster- and Leipzig-Germany, Varese-Italy, Uppsala-Sweden)
  • > 7500 / 8500 / 1050 citations (Scopus, WoS/ResearchGate/Scholar Google)
  • H-index = 42 / 44 / 52 (Scopus, WoS/ResearchGate/Scholar Google)

Supervisor for 16 Ph.D. and 35 M.Sc. awarded studies, 3 PhD and 4 MSc under progress,

Collaborations and Research Networks 
Collaboration at International level with Karolinska Institute, School of Medicine, Sweden, the University of Insubria, School of Medicine, Varese-Italy, Unviversity at Reims France, School of Medicine and University of Munster, School of Medicine, Germany) Several other collaborations in Europe, USA, Japan and Brazil have been established.
Coordinator of the University of Patras Research Network: Biotargeting - Biomedical and Biotechnological Applications Research Network. (

Research Project 
Coordination of a number of National (15) and International (5) research projects.
Major recent projects:
- Co-financed by the European"Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF) - Research Funding Program: Thales. Investing in knowledge society through the European Social Fund Union (European Social Fund – ESF) and Greek national funds through the Operational Program 
- Funded by MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) [Grant Agreement number: 645756 — GLYCANC — H2020-MSCA-RISE-2014] for the Action: "Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer". Collaborators: WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITA DEGLI STUDI DELL'INSUBRIA, UPPSALA UNIVERSITET, NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS", SEREND-IP GMBH, FIDIA FARMACEUTICI SPA, SEMMELWEIS EGYETEM, CAIRO UNIVERSITY.

Useful links
Departmental & Personal website: 
List of Publications:


Undergraduate teaching: 
Biochemistry I, Clinical Chemistry
Graduate teaching: Courses Master & Ph.D.:
Advanced Biochemistry I and II, Molecular Biology & Molecular Biotechnology, Clinical Biochemistry,Analytical Biochemistry, Applications of Biochemistry and Biotechnology (lab)

Research Activities

Matrix Biology, Cell Signaling, Functional Cell Properties, Pharmacological Targeting at Molecular and Cellular Levels, Biological Testing, Cell mimetic models for cancer metastasis, Structure Analysis of Carbohydrates and Evaluation of Cytotoxicity.
• Structure and functions of metalloproteinases (MMPs), cell bound and cell-secreted proteoglycans (PGs)/ glycosaminoglycans (GAGs) and acidic glyco- and sialoproteins in malignancy.
• Effects of growth factors and their receptors on gene expression and synthesis of MMPs and PGs
• Structure, function, immunological and biological properties of carbohydrates, proteoglycans and glycoproteins
• Carbohydrates and related compounds produced from pathogenic bacteria
• Evaluation of pharmacological agents at molecular and cellular levels (functional cell properties, receptors and intracellular pathways, gene expression and regulation)
• Health and Safety issues: toxicity evaluation at cell level
• Development, validation and biological applications of high-performance liquid chromatographic & capillary electrophoresis methods for fine biochemical and structural analysis of carbohydrates, proteoglycans and glycoproteins in biological samples (Cell cultures, tissues, biological matrices)
• Structure, analysis and interactions of important biological molecules (growth factors/peptides, amino acid derivatives)


  • Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
    Karamanos NK, Piperigkou Z, Theocharis AD et al ,
    Chem Rev. 2018 Sep 26;118(18):9152-9232.
  • Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics: Karamanos NK, Piperigkou Z, Theocharis AD et al ,
    Chem Rev. Sep 26;118(18):9152-9232 (2015)
  • Extracellular matrix structure: Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK.
    Adv Drug Deliv Rev.(2015)
  • Insights into the key roles of proteoglycans in breast cancer biology and translational medicine:Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK. 
    Biochim Biophys Acta Rev on Cancer(2015)
  • Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.
    Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK.
    Matrix Biol. (2015
    ) 43:42-60
  • Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans
    Skandalis, N. Afratis, G. Smirlaki, D. Nikitovic, A. Theocharis, G. Tzanakakis, N. K. Karamanos 
    Matrix biology(2013)
  • Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid
    PG Dedes, C Gialeli, AI Tsonis, I Kanakis, AD Theocharis, D Kletsas, GN Tzanakakis and NK Karamanos.
    Biophys. Acta-General Subjects1820(12) (2012) 1926-39.
  • Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.
    Gialeli C, Theocharis AD, Karamanos NK.
    FEBS J.(2011) 278(1):16-27
  • Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting. 
    D. Theocharis, S.S .Skandalis, G.N. Tzanakakis and N.K. Karamanos.
    FEBS J.277 (2010) 3904-23
  • The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis. 
    Zarogoulidis, E. Boutsikou, P. Zaropoulidis, E. Eleftheriadou, T. Kontakiotis, G.N. Tzanakakis, J. Kanakis, N. K. Karamanos
    Int J Cancer125 (1) (2009) 705-709.

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