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Karamanos Nikos

Karamanos N.
Karamanos N.

Professor

Tel: (+302610) 997915, 997181

e-mail:

Web Page : http://www.chem.upatras.gr/faculty/karamanos

List of Publications: Google Scholar

Contact hours: Monday 13:00-15:00, Tuesday 09:00-11:00

Curriculum Vitae

Professor of Biochemistry and Org. Biochem. Analysis, Dept. of Chemistry, Univ. of Patras.

Education and degrees
1984 & 1988: Diploma (Chemistry, grade A) and Ph.D. (Biochemistry, grade A), Dept Chem., University of Patras
1987-1999: Researcher and Post doc Research Fellow (annual periods, total 3-years) at Karolinska Institute, Dept. of Laboratory Medicine, School of Medicine, Stockholm, Sweden
1990-2002: Lecturer (1990), Assistant Professor (1993), Associate Professor (1999), Dept of Chemistry, University of Patras
2003-present: Professor of Biochemistry & Org. Biochem. Analysis, University of Patras
2004-present: Member of the administrative board of the Hellenic Society of Biochemistry & Molecular Biology (HSBMB) as President (2006-2007, 2011, 2018-2019), General Secretary (2004-2005 & 2011), Vice-President (2008-2011 & 2017-2018)
2003-present: Coordinator of the Hellenic Matrix Biology section of HSBMB (former Hellenic Research Club for Connective Tissue and Matrix Biology) and contact person in the European Matrix Biology Society (former Federation of European Connective Tissue Societies-FECTS)
2007-2009: European Union Expert, FP7, theme “Health”
2010-present: Collaborative Faculty Member of the Institute ICE-HT (FORTH), Patras, Greece
2007-2011: Head of the Department of Chemistry, University of Patras
2011: European Registered Toxicologist (ERT)
2012-2020: Member of the Quality Assurance Unit of the University of Patras (MODIP) and president 2014-2020
2014-2020: Vice-Rector of Academic & International Affairs
2019-2020: Council member of the International Society for Matrix Biology (ISMB)
2021-present: Vice-president of ISMB

Editorial Scientific Boards/Reviewer & Awards:
Member of the editorial boards of several peer-review journals. Among them: Matrix Biology and Matrix Biology Plus (deputy editor), FEBS Journal (editor 2020- present, editorial advisory board 2010-2019), PLoS ONE (academic editor), The Journal of Biological Chemistry (2009-2014), Current Medicinal Chemistry, Biomedical Chromatography, Current Pharmaceutical Analysis, Current Chemical Biology, Chromatographia (2004-2009), Data Sets in Biology, Science Open, and several other scientific journals.
Participation in the editorial boards and action as reviewer in peer review scientific journal (>50) in the areas of Biochemistry, Biochemical & Pharmaceutical Analysis, Cancer Cell Biology, Molecular Biology, Anticancer Agents, Matrix Biology, Extracellular Matrix, Cell signaling, Targeted Molecular Therapeutic Approaches, Drug Pharmacological Evaluation.
A number of awards has been conferred by various Scientific Societies, among them the Hellenic Society of Biochemical & Molecular Biology Society, Society for Microbiology and Biopathology, Pediatrics, Society for Anticancer Research, European associated Societies Comet and Leonardo Da Vinci, Neurological Society, Federation of European Connective Tissue Societies, etc.
Several publications on the field of Matrix Biology, especially pharmacological targeting of metalloproteinases and proteoglycans were among the top most-cited publications in FEBS J in 2013 and 2014 and those published in the last fifty years of the journal. According to BiomedExperts and Scholar websites  Dr. Karamanos is among the top authors and most cited in the areas: Matrix Biology, Glycosaminoglycans, Proteoglycans and Metalloproteinases.

Quest editor/Editor:

  1. International Book Series: Biology of Extracellular Matrix, Springer-Nature [Series Editor since 2018]
  2. International Book Edition: Extracellular Matrix: Pathobiology and Signaling, ISBN 978-3-11-025876-9 (2012), Walter DeGruyter, Berlin/Boston, p1-890 [Editor]
  3. Special Issue: Matrix Effectors and Cancer, Cancers (2021) [Guest Editor with Z.Piperigkou]
  4. Special issue: Translating Extracellular Matrix: from Cancer Progression to Therapeutics, Seminars in Cancer Biology (2020) 62; iii-v [Guest Editor]
  5. Special issue: Complexity of Matrix Phenotypes, Matrix Biol Plus (2020) In press [Guest Editor with R.V. Iozzo]
  6. Special issue: Matrix Modeling and Remodeling: Proteoglycans remodeling in cancer: Underlying molecular mechanisms, Matrix Biology (2019), 75-76;1-330 [Guest Editor]
  7. Special issue: Extracellular Matrix in Health and Disease, FEBS J (2019), 286;2823-3075 [Guest Editor]
  8. MiniReview Series: Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease, FEBS J (2017) 284;7-9 [Coordinator]
  9. Special Issue: Matrix-mediated cell behavior and properties, Biochimica et Biophysica Acta (2014) 1840;2385 [Guest Editor]
  10. MiniReview Series: Novel insights into matrix pathobiology regulatory mechanisms in health and disease, FEBS J (2014) 281;4978-4979 [Coordinator with A. Passi]
  11. Special Issue: Proteoglycans signaling, targeting and therapeutics, FEBS J (2013) 280;2119-2534 [Guest Editor with R. Linhardt]
  12. MiniReview Series: Regulatory roles of hyaluronan in health and disease, FEBS J (2011) 278;1411 [Coordinator with V. Hascal]
  13. MiniReview Series: Metalloproteinases in Health and Disease: challenges and the future prospects, FEBS J (2011) 278;1 [Coordinators with H. Nagase]
  14. MiniReview Series: Proteoglycans in Health and Disease: emerging concepts and future directions, FEBS J (2010) 277;3863 [Coordinator with R.V. Iozzo]
  15. Special issue: Matrix Pathobiology, Signaling and Molecular Targets, Conn. Tissue Res. (2008) 49 (3&4) [Guest Editor]
  16. Special issue: Solid phase assays for molecules with biopharmaceutical importance, J Pharm Biomed Anal, Elsevier (2004) 34 [Guest Editor]
  17. Special issue: Analysis of carbohydrate macromolecules by capillary electrophoresis: glycoproteins, proteoglycans/glycosaminoglycans and glycolipids, Biomed Chromat, Wiley InterScience (2002) 16 [Guest Editor]

Organization of workshops, meetings/symposia, Editorial Boards, Honors and awards

Chairman of the FEBS Advanced lecture Courses (organized every other year since 2007) in the thematic area: Matrix Pathobiology, Signaling and Molecular Targets: (www.chemistry.upatras.gr/febs-mpst2007www.febs-mpst2009.upatras.grwww.febs-mpst2011.upatras.grwww.febs-mpst2013.upatras.grwww.febs-mpst2015.upatras.grwww.febs-mpst2017.upatras.gr, https://mpst2019.febsevents.org).

Chairman of the FEBS ALC on Extracellular Matrix, Cell Regulation and Epigenetics (https://extracellularmatrix.febsevents.org). 

Co-chair of the International Conference on Proteoglycans, Seven Lakes-Italy, 2017.

Chairman of the 60th Hellenic Conference of the Hellenic Society of Biochemistry & Molecular Biology, Athens, 2009.

Scientific Secretary and International Contact person of the 33rd FEBS Congress-11th IUBMB Conference (2008). Secretary of the 17th FECTS International Conference (2000).

Chairman of the Commet EU Training Course on Advanced analytical techniques (1992) and Leonardo Da Vinci EU meeting on Microseparation techniques (1998). Member of the organizing committee of a series of scientific meetings of the Hellenic Connective tissue and Extracellular Matrix section, and of the 1st and 2nd Conference of Biosciences of the University of Patras as well as in a series of international conferences.

Publications/books/lectures

  • More than 300 publications (Research and Reviews) in international peer review journals.
  • 1 International book with 54 chapters and 7 thematic sections, Published by DeGruyter, 2012, Berlin/Boston
  • 35 Publications as chapters in book series and full proceeding
  • 3 books on biomolecules structure-function and enzyme immunoassays 
  • More than 350 abstracts in proceedings of International and National scientific conferences
  • More than 100 invited, confirmed and plenary lectures in International meetings/conferences (including FECTS-2004 Italy, FEBS-2010 Sweden, Gordon Research Conference on Proteoglycans-2012, 2014, 2016 USA, International Proteoglycans' conference, 2013 & 2015 Germany and Seoul), Hellenic scientific conferences and International Research Institutes and Universities (including University of Reims and Paris-France, Munster- and Leipzig-Germany, Varese-Italy, Uppsala-Sweden)
  • > 14,000 citations & h-index =59 (Scholar Google)

Trainees
Supervisor for 18 Ph.D. and 35 M.Sc. awarded studies, 3 PhD and 4 MSc under progress,

Collaborations and Research Networks 
Collaboration at International level with Karolinska Institute, School of Medicine, Sweden, the University of Insubria, School of Medicine, Varese-Italy, University at Reims France, School of Medicine and University of Munster, School of Medicine, Germany) Several other collaborations in Europe, USA, Japan and Brazil have been established.
Coordinator of the University of Patras Research Network: Biotargeting - Biomedical and Biotechnological Applications Research Network. (www.biotargeting.upatras.gr).

Research Project 
Coordination of a number of National (15) and International (5) research projects.
Major recent projects:
- Co-financed by the European"Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF) - Research Funding Program: Thales. Investing in knowledge society through the European Social Fund Union (European Social Fund – ESF) and Greek national funds through the Operational Program 
- Funded by MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) [Grant Agreement number: 645756 — GLYCANC — H2020-MSCA-RISE-2014] for the Action: "Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer". Collaborators: WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITA DEGLI STUDI DELL'INSUBRIA, UPPSALA UNIVERSITET, NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS", SEREND-IP GMBH, FIDIA FARMACEUTICI SPA, SEMMELWEIS EGYETEM, CAIRO UNIVERSITY.

Useful links
Departmental & Personal website: www.chem.upatras.gr/faculty/karamanos


Courses

Undergraduate teaching: Biochemistry I & Biochemistry II, Clinical Chemistry
Graduate teaching: Courses Master & Ph.D.: Advanced Biochemistry I and II, Molecular Biology & Molecular Biotechnology, Clinical Biochemistry, Analytical Biochemistry, Applications of Biochemistry and Biotechnology (lab)


Research Activities

Matrix Biology, Cell Signaling, Functional Cell Properties, Pharmacological Targeting at Molecular and Cellular Levels, Biological Testing, Cell mimetic models for cancer metastasis, Structure Analysis of Carbohydrates and Evaluation of Cytotoxicity.
• Structure and functions of metalloproteinases (MMPs), cell bound and cell-secreted proteoglycans (PGs)/ glycosaminoglycans (GAGs) and acidic glyco- and sialoproteins in malignancy.
• Effects of growth factors and their receptors on gene expression and synthesis of MMPs and PGs
• Structure, function, immunological and biological properties of carbohydrates, proteoglycans and glycoproteins
• Carbohydrates and related compounds produced from pathogenic bacteria
• Evaluation of pharmacological agents at molecular and cellular levels (functional cell properties, receptors and intracellular pathways, gene expression and regulation)
• Health and Safety issues: toxicity evaluation at cell level
• Development, validation and biological applications of high-performance liquid chromatographic & capillary electrophoresis methods for fine biochemical and structural analysis of carbohydrates, proteoglycans and glycoproteins in biological samples (Cell cultures, tissues, biological matrices)
• Structure, analysis and interactions of important biological molecules (growth factors/peptides, amino acid derivatives)


Representative Publications

  • Estrogen receptor-mediated targeting of the extracellular matrix network in cancer. Piperigkou Z,Karamanos NKSeminars in Cancer Biology (2020)
  • Dynamic Interplay between miRNAs and the Extracellular Matrix Influences the Tumor Microenvironment. Piperigkou Z, Karamanos NK.Trends in Biochemical Sciences (2019)
  • Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics. Karamanos NK, Piperigkou Z, Theocharis AD et al,  Chemical Reviews 26;118(18):9152-9232 (2018)
  • Extracellular matrix structure: Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Adv Drug Deliv Rev (2016)
  • Insights into the key roles of proteoglycans in breast cancer biology and translational medicine: Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK.  Biochim Biophys Acta Reviews on Cancer (2015)
  • Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells. Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK. Matrix Biol. 43:42-60 (2015)
  • Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: Focus on the role and impact of proteoglycans. Skandalis S, Afratis N, Smirlaki G, Nikitovic D, Theocharis A, Tzanakakis G, Karamanos NK. Matrix biology (2013)
  • Glycosaminoglycans: key players in cancer cell biology and treatmen. Afratis, N,  Gialeli Ch,  Nikitovic D,  Tsegenidis T,  Karousou E, Theocharis AD,  Pavao M,  Tzanakakis G, N.;  Karamanos NK. FEBS J https://doi.org/10.1111/J.1742-4658.2012.08529.X (2012)
  • Roles of matrix metalloproteinases in cancer progression and their pharmacological Gialeli C, Theocharis AD, Karamanos NK.
    FEBS J. 278(1):16-27 (2011)
  • Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting. Theocharis D, Skandalis S.S., Tzanakakis G.N. and Karamanos N.K. FEBS J. 277, 3904-23 (2010)

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