Vynios Demitrios

Vynios D.
Vynios D.


Tel: (+302610) 997914

Fax: (+302610) 997154


Web Page: http://www.chem.upatras.gr/faculty/vynios

List of publications:

Contact hours: 12.00-13.00, daily

Curriculum Vitae

1976-1980 Graduate studies in the Department of Chemistry of the University of Patras
1981-1987 Research Assistant, Chair of Biochemistry, Department of Chemistry, University of Patras
1987 Ph.D. in Biochemistry
1988-1993 Lecturer of Biochemistry, Department of Chemistry, University of Patras
October 1988 Post-Graduate Sudies in immunosorbent assays, Hellenic Pasteur Institute, Athens, Greece
1990-1991 Research associate in the Kennedy Institute of Rheumatology, London, UK.
1993-1999 Assistant Professor of Biochemistry, Department of Chemistry, University of Patras
1999-2006 Associate Professor of Biochemistry, Department of Chemistry, University of Patras

2007-today Professor of Biochemistry, Department of Chemistry, University of Patras

Invited Editor
"Mimetic peptides in allergy and inflammation treatment"
D. H. Vynios
Anti-Inflammatory and Anti-allergy Agents in Medicinal Chemistry, January 2009 (www.bentham.org)

"Osteoarthritis and its treatment"
D. H. Vynios
Current Medicinal Chemistry: Anti-Inflammatory and Anti-allergy Agents, June 2005 (www.bentham.org)

Honours and awards
Best poster award for the poster
“The diagnostic significance of collagen type IX and HNK-1 epitope in XFS",
M.S. Assouti, C.D. Georgakopoulos, S.P. Gartaganis and D.H. Vynios,
presented in XIXth FECTS Meeting, Taormina, Italy, 2004.

A figure of the paper
"The increased accumulation of structurally modified versican and decorin is related with the progression of laryngeal cancer»,
SS Skandalis, AD Theocharis, N Papageorgakopoulou, DH Vynios, DA Theocharis, Biochimie, 88, 1135-1143 (2006) has been selected as front cover of the Journal.

Editorial board
Anti-Inflammatory and Anti-allergy Agents in Medicinal Chemistry, since 2006 (www.bentham.org)

World Journal of Gastroenterology, since 2013 (http://www.wjgnet.com)

• > 85 publications in peer-reviewed scientific journals / web pages.
For a detailed list of publications in scientific journals visit:   www.publicationslist.org/vynios
• 5 book chapters
• 5 students’ text books  
• > 350 abstracts in Panhellenic and International conferences
• > 30 invited lectures in Panhellenic and International conferences / symposia, as well as in Research Institutes and Universities
• 3 invited publications in web pages
• > 1200 citations
• H-index = 20

Supervisor for 8 Ph.D. and 29 M.Sc. awarded studies, 2 PhD and 6 MSc under progress, For further details see the attachment.

Collaborations and Research Networks

Collaboration at international level with: Research Unit MEDyc, University of Reims (France)

Collaboration at National level with: School of Medicine and Pharmacy (Univ. of Patras), University Hospital (Patras) και School of Mechanical Engineering (Univ. Of Patras).

Participation in the University of Patras Research Network: Biotargeting - Biomedical and Biotechnological Applications Research Network. (http://www.biotargeting.upatras.gr/).

Participation in the University of Patras Research Network: OsteoNet: Network for the Study of Degenerative and Metabolic Diseases of bone and Cartilage. (http://www.osteonet.gr/)

For more information: http://www.biomedexperts.com/Profile.bme/1497763/Demitrios_H_Vynios

Research Projects
Coordination of a number of National research projects


Graduate Programme

  1. Biochemistry Ι (tutorials)
  2. Biochemistry ΙΙ (Laboratory excercises)
  3. Biochemistry III (Lectures, Laboratory excercises)
  4. Biotechnology (Lectures, Laboratory excercises)
  5. Clinical Chemistry (Laboratory excercises)
  6. Instrumental Analysis of Biomolecules (Lectures)
  7. Microbiology (Lectures, Laboratory excercises)

Post-graduate Programme

  1. Biochemical Analysis – Clinical Chemistry
  2. Molecular Biology and Molecular Biotechnology

Research Activities

1. Isolation, macromolecular structure, biochemical characterisation, and immunological properties of proteoglycans and glycosaminoglycans of various organisms, under normal and pathologic conditions  
2. Isolation and characterisation of enzymes of various organisms, under normal and pathologic conditions
3. Development and application of bioanalytical methods
4. Hydroxyapatite formation in vivo and in vitro
5. Macromolecular interactions of extracellular matrix macromolecules
6. Development and application of methods for the detection of proteoglycan autoantibodies in serum
7. Expression of extracellular macromolecules in cell cultures
8. Production of Biofuels from wastes
9. Preparation and examinations of tissue engineering scaffolds

Representative Publications

Detailed list of publications http://www.biomedexperts.com/Profile.bme/1497763/Demitrios_H_Vynios

  • K. Karamanou, M. Franchi, Z. Piperigkou, C. Perreau, F. X. Maquart, D. H. Vynios, S. Brézillon
    Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition
    Sci Rep. 2017;7:45138. doi: 10.1038/srep45138
  • Z. Piperigkou, K. Karamanou, N.A. Afratis, P. Bouris, C. Gialeli, C.L. Belmiro, M.S. Pavão, D.H. Vynios, A.M. Tsatsakis
    Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules
    Toxicol Lett. 2016;240:32-42. doi: 10.1016/j.toxlet.2015.10.005
  • T. Panogeorgou, E. Tserbini, S. Filou, D.H. Vynios, S.S. Naxakis, T.A. Papadas, P.D. Goumas, N.S. Mastronikolis
    Hyaluronan synthases and hyaluronidases in nasal polyps
    Eur Arch Otorhinolaryngol. 2016;273(7):1801-8. doi: 10.1007/s00405-015-3848-6
  • S. Filou, A. Korpetinou, D. Kyriakopoulou, D. Bounias, M. Stavropoulos, P. Ravazoula, D. J. Papachristou, A. D. Theocharis, D. H. Vynios
    ADAMTS expression in colorectal cancer
    PLoS One. 2015 Mar 18;10(3):e0121209
  • DH Vynios
    Metabolism of cartilage proteoglycans in health and disease.
    Biomed Res Int. 2014;2014:452315. doi: 10.1155/2014/452315 http://www.hindawi.com/journals/bmri/2014/452315/
  • D. Barbouri, N. Afratis, C. Gialeli, D.H. Vynios, A.D. Theocharis and N. K. Karamanos
    Syndecans as modulators and potential pharmacological targets in cancer progression.
    Frontiers Oncol. (2014) doi: 10.3389/fonc.2014.00004 http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00004/full
  • G. Tsiropoulos, T. Papadas, I.-E. Triantaphyllidou, S. Naxakis, K. Markou, S. Triaridis, I. Vital, P. Goumas, D.H. Vynios
    Pre-treatment gelatinases’ serum levels and post-treatment changes in laryngeal cancer patients
    HIPPOKRATIA 17 (2013) 126-129.
  • C. Kolliopoulos, D. Bounias, H. Bouga, D. Kyriakopoulou, M. Stavropoulos, D.H. Vynios
    Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients
    J. Pharm. Biomed. Anal. 83C (2013) 299-304. doi: 10.1016/j.jpba.2013.05.037
  • E Pagoulatou, I-E Triantaphyllidou, DH Vynios, DJ Papachristou, E Koletsis, D Deligianni, D Mavrilas,
    Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold. J. Mater. Sci.: Mater. Med. 23 (2012) 1387-1396. http://link.springer.com/article/10.1007%2Fs10856-012-4620-8
  • H Bouga, I Tsouros, D Bounias, D Kyriakopoulou, MS Stavropoulos, N Papageorgakopoulou, DA Theocharis, DH Vynios
    Involvement of hyaluronidases in colorectal cancer
    BMC Cancer 2010, 10:499 http://www.biomedcentral.com/1471-2407/10/499


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