Aletras Alexios

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Aletras A.
Aletras A.

Associate Professor

Tel: (+302610) 997161

Fax: (+302610) 997154

e-mail:

Web Page: http://www.chem.upatras.gr/faculty/aletras

Curriculum Vitae

Education
1972-1977: Undergraduate studies in the Department of Chemistry, University of Patras, Diploma in Chemistry.
1978-1982: Post-graduate studies in the Department of Chemistry, University of Patras, accomblishment of PhD Thesis entitled: “Interaction of hyaline cartilage glycoproteins with hyaluronic acid and proteoglycans; characterization of proteoglycans”.
1985: PhD in Biochemistry.

Academic career
1981-1986: Research Assistant in the Laboratory of Biochemistry, Department of Chemistry, University of Patras.
1987-1992: Lecturer of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras.
1992-2003: Assistant Professor of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras.
2003-today: Associate Professor of Biochemistry, Section of Organic Chemistry, Biochemistry and Natural Products, Department of Chemistry, University of Patras.


Courses

I)Undergraduated
1. Biochemistry-2 (Lectures, Tutorials)
2. Biochemistry-1 (Tutorials)
3. Biochemistry (Laboratory exercises)
4. Biochemistry-3 (Lectures, Tutorials)

II) Post-Graduated
1.Advanced Biochemistry
2. Molecular Pharmacology-Immunology
3. Biochemical Analysis-Clinical Biochemistry
4. Applications in Biochemistry and Biotechnology (Laboratory exercises)


Research Activities

1.Isolation and characterization of extracellular matrix macromolecules (glycosaminoglycans, proteoglycans, glycoproteins) from several types of connective tissue and study of their interactions.
2. Studies on extracellular matrix metalloproteinases (MMPs). Investigation of their role in several pathologic conditions such as, cancer proliferation and metastasis, arhtritis, arthroplasty loosening, skin and lung diseases, eyes pterygium and nasal polyposis.
3. The role of TGF-β1, IGF-I and MIF in the pathogenesis of arthritis, lung diseases, eyes pterygium and nasal polyposis. Study of their effects on the production of MMPs, TIMPs, collagen, cytokines and prostaglandins by synovial, lung, pterygium and nasal polyps fibroblasts, and articular chondrocytes. Investigation of signal transduction pathways mediating these effects.
4. The role of proteasome in the pathogenesis of osteoarthritis, eyes pterygium and nasal polyposis. Study of its effect on the expression of MMPs, TIMPs, cytokines and collagen in fibroblasts and chondrocytes.


Representative Publications