Athanassopoulos Constantinos

Athanasopoulos ...
Athanasopoulos K.


Tel: (+302610) 997909

Fax: (+302610) 997156


Web Page:

List of Publications:

Contact hours: Tuesday 10:00-12:00, Thursday 10:00-12:00

Curriculum Vitae

2016-today : Associate Professor of Organic Chemistry, Department of Chemistry, University of Patras,

-2018 (April 11th to July 25th) : Visiting Professor for Research at  "La Sapienza" - Università di Roma, Italy

-2017 (September 11th to October 10th) : Visiting Professor at Universitè Paul Sabatier, Toulouse, France

03/2010-present: Assistant Professor of Organic Chemistry, Dept. of Chemistry, University of Patras, Greece.

03/2006-03/2010: Lecturer in Organic Chemistry, Dept. of Chemistry, University of Patras, Greece.
2005-2006: Postdoctoral Research Fellow in the Department of Chemistry, University of Patras, Greece. Scholarship by the Greek State Scholarship's Foundation (IKY).

1995-1996 Researcher in the Dept. of Chemistry, University of Calabria, Cosenza, ITALY (12 months, Human Capital And Mobility, EU Fellowship)

1994: Researcher in the Dept. of Chemistry, University of Minho, Braga, PORTUGAL (2 months, Human Capital And Mobility, EU Fellowship).

1991 & 2003: Diploma in Chemistry and Ph.D. in Organic Chemistry by the Dept. of Chemistry, University of Patras, Greece


Professional Societies

American Chemical Society,
Royal Society of Chemistry,
American Society for Mass Spectrometry,
Association of Greek Chemists

Proposal reviewer for

REPRISE/ CINECA, Ministero dell'Istruzione dell'Università e della Ricerca,  ITALY
Kingdom of Saudi Arabia, Ministry of  Education,  SAUDI ARABIA
General Secretariat for Research and Technology (GSRT), GREECE


Human Capital & Mobility EU Fellowships (1994, 1995, 1996).
Scholarship by the Greek State Scholarship's Foundation (IKY) for Postdoctoral Research, 2005.
“Pythagoras II” Program Fellowship for Postdoctoral Reasearch 2005-2006.
YYDRASIL Fellowship from the Research Council of Norway for Postdoctoral Research at the University of Bergen, Norway, 2009


June 1993 & July 1996: NATO Advanced Study Institute (ASI) on Mass Spectrometry in the Biomolecular Science, Lacco Ameno, Ischia and Altavilla Milicia, Palermo, ITALY respectively.
September 2004: Ischia Advanced School of Organic Chemistry (IASOC 2004), Ischia, ITALY.


I)Undergraduated courses

Organic Chemistry of Functional Groups II (Dept. of Chemistry, UoP)
Spectroscopy of Organic compounds (Mass Spectrometry, Dept. of Chemistry UoP)
Synthetic Organic Chemistry (Dept. of Chemistry, UoP)
Experimental Organic Chemistry I (Dept. of Chemistry, UoP)
Experimental Organic Chemistry II (Dept. of Chemistry, UoP)

II)Post-Graduated courses

Organic Synthesis of Drugs (MSc Programme 'Medicinal Chemistry and Chemical Biology';Depts. of Chemistry and Medicine, UoP).
Analysis of bioactive Molecules (MSc Programme 'Medicinal Chemistry and Chemical Biology';Depts. of Chemistry and Medicine, UoP).
Synthetic Inorganic, Organic and Organometallic Chemistry (MSc Programme 'Synthetic Chemistry'; -Functional Group Interconversions-, Dept. of Chemistry)
Investigating the Micro- and Nano-World: Microscopy (MSc Programme 'Analytical Chemistry'; -Mass Spectrometry-, Dept. of Chemistry)

Research Activities

Synthetic Organic and Medicinal Chemistry [main]

  • Discovery and development of small organic molecules and of natural product analogues/ derivatives (e.g. abietanes; polyamines; endoperoxides; retinoids; psoralens) with anticancer (Hedgehod pathway inhibitors; Cancer Stem Cell differentiators; Anti-angiogenic agents), antibacterial (against MRSA strains) and antimalarial activity.
  • Synthesis of Multitarget Inhibitors and of Hybrids or Bioconjugates aiming at improvement of the pharmacological profile of a bioactive compound

Mass Spectrometry [secondary]

  • Synthesis of labeling reagents (heavy/ light) for applications in analysis by Mass Spectrometry.
  • Solid Phase Synthesis of “chemical probes” for applications in Mass Spectrometry Proteomics.

Representative Publications

  • Panagiota C. Giannopoulou, Dionissia A. Missiri, Georgia G. Kournoutou, Eleni Sazakli, Georgios E. Papadopoulos, Dionissios Papaioannou, George P. Dinos *, Constantinos M. Athanassopoulos * and Dimitrios L. Kalpaxis † “New Chloramphenicol Derivatives from the Viewpoint of Anticancer and Antimicrobial Activity” Antibiotics, 2019, 8 (1), 9
  • M. Athanassopoulos*, G.E. Magoulas, T. Tsigkou, L. Skondra, M. Lamprou, P. Tsoukala, V. Kokkinogouli, E. Pantazaka, D. Papaioannou, E. Papadimitriou “Synthesis of nοvel artemisinin dimers with polyamine linkers and evaluation of their potential as anticancer agents”
    Bioorganic & Medicinal Chemistry, 2017, 25
    (14), 3756-3767
  • Antoniou, A. I.; Pepe, D. A.; Aiello, D.; Siciliano, C.; Athanassopoulos, C. M.*,   “Chemoselective Protection of Glutathione in the Preparation of Bioconjugates: The Case of Trypanothione Disulfide“
    The Journal of Organic Chemistry  2016, 81 (10), 4353-4358.
  • Magoulas, O.N. Kostopoulou, C.M. Athanassopoulos,T. Garnelis, G.G. Kournoutou, M. Leotsinidis, G.P. Dinos, D. Papaioannou, D.L. Kalpaxis
    “Synthesis and antimicrobial activity of chloramphenicol–polyamine conjugates”.
    Bioorg. Med. Chem., 
    2015, 23, 3163-3174.
  • Bariamis, M. Marin, C. M. Athanassopoulos, C. Kontogiorgis, Z. Tsimali, D. Papaioannou, G. Sindona, G. Romeo, K. Avgoustakis and D. Hadjipavlou-Litina.
    “Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives”.
    Eur. J. Med. Chem.,2013, 60, 155-169.
  • Napoli*, M. Athanassopoulos*, P. Moschidis, D. Aiello, L. Di Donna, F. Mazzotti, G. Sindona
    “Solid Phase Isobaric Mass Tag Reagent for Simultaneous Protein Identification and Assay”.
    Analytical Chemistry, 2010, 82, 5552-5560.
  • Militsopoulou M; Bariamis S.E; Athanassopoulos C.M;and Papaioannou D.
    “Synthetic Studies towards the Development of Psoralen-Acidic Retinoid Conjugates and Hybrids”.
    Synthesis, 2008, (21), pp. 3433-3442.
  • Athanassopoulos, C.M.; Garnelis, T.; Magoulas, G. and Papaioannou, D.
    "Efficient Syntheses of Polyamines Bearing 1H-Tetrazolyl Units on their Amino Functions".
    Synthesis2006, 18, 3134.
  • Athanassopoulos, C.M.; Garnelis, T.; Vahliotis, D. and Papaioannou, D. 
    "Efficient Syntheses of 5-Aminoalkyl-1-H-tetrazoles and of Polyamines Incorporating Tetrazole Rings". 
    Lett.2005, 7, 561.
  • Athanassopoulos, C.M.; Garnelis, T.; Papaioannou, D.; Eggleston I.M. and Fairlamb A.H
    "Very Short And Efficient Syntheses of the Spermine Alkaloid Kukoamine A and Analogs Using Isolable Succinimidyl Cinnamates".
    Chem. Lett. 2005, 34, 264.

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