Tselios Theodore

Tselios T.
Tselios T.


Tel: (+302610) 997905

Fax: (+302610) 997180


Web Page: http://www.chem.upatras.gr/faculty/tselios

List of Publications:

Contact hours: Wednesday and Friday 11:00-13:00

Curriculum Vitae

Associate Professor Theodore Tselios was born in Messolonghi, Greece. He obtained his diploma (Chemistry) in 1994, PhD (Organic Chemistry) in 2001 and MSc (Medicinal Chemistry) in 2003 from the Department of Chemistry, University of Patras. He has joined several times, as a visiting scientist, collaborating laboratories abroad such as Austin Research Institute, Melbourne Australia, School of Chemistry, University of Cardiff, UK, Department of Chemistry, University of Florence Italy etc.

He has been honoured by "Leonidas Zervas foundation" of Greece (1998) and he had a scholarship by the State Scholarship’s Foundation of Greece, (2002-2003).

He has published seventy (70) research articles, 52 the last ten years, in the field of rational drug design, synthesis and evaluation of bioactive molecules. He has twenty-two publications (22) as first or second author and twenty-eight (28) as corresponding author in several journals. Nine (9) research articles were published in "Journal of Medicinal Chemistry", one (1) in "Brain" and four (4) reviews in "Current Medicinal Chemistry". He has published nine (9) book chapters, forty-seven (47) abstracts in international conferences, seventy-three (73) international conference proceedings and ninety-five (95) national (Greek) conference abstracts. Moreover, figures of his research articles have been selected as cover pages in four (4) issues of "Current Medicinal Chemistry".

He has participated in the Organizing Committee of International Conferences (32nd European Peptide Symposium, 32nd and 29th Cyprus-Camerino-Noordwijkerhout: Trends in Drug Research Medicinal Chemistry EFMC Symposium, SEEDRUG project: NMR Applications in Life Sciences - Exploring Peptides & Proteins).

Since 2004, he has joined the faculty of Chemistry Department of the University of Patras as a Lecturer (2004-2009), Assistant Professor (2009-2015) and Associate Professor (2015-today).


Undergraduate teaching


  1. "Organic Chemistry III" - Department of Chemistry (until 2011)
  2. "Organic Chemistry" - Department of Chemical Engineering (until 2011).
  3. "Organic Chemistry of Functional Groups I" - Department of Chemistry.
  4. "Organic Chemistry of Functional Groups II" - Department of Chemistry.
  5. "Experimental Organic Chemistry I" (Theory) - Department of Chemistry.
  6. "Experimental Organic Chemistry II" (Theory) - Department of Chemistry.


  1. Experimental Organic Chemistry I - Department of Chemistry.
  2. Experimental Organic Chemistry II - Department of Chemistry.

Graduate teaching


  1. "NMR Spectroscopy and Molecular Design" - Interdepartmental Master Degree Program "Medicinal Chemistry: Drug Discovery and Design", Departments of Chemistry, Pharmacy & Medicine (until 2018).
  2. "Synthetic Inorganic, Organic & Organometallic Chemistry" (Heterocyclic Chemistry) - Master Degree Program "Synthetic Chemistry & Advanced Polymeric & Nanostructured Materials", Department of Chemistry (until 2018).
  3. "Structural and Computational Medicinal Chemistry" - Interdepartmental Master Degree Program "Medicinal Chemistry and Chemical Biology", Departments of Chemistry & Medicine.


  1. "Laboratory of Medicinal Chemistry" (Synthetic Chemistry & Molecular Design) - Interdepartmental Master Degree Program "Medicinal Chemistry: Drug Discovery and Design", Departments of Chemistry, Pharmacy & Medicine (until 2018).

Research Activities

  1. Organic, Peptide and Medicinal Chemistry. Rational design and synthesis of linear, cyclic peptide analogues and non-peptide mimetics.
  2. Conformational studies and Molecular Modelling of bioactive and pharmaceutical molecules. Interactions of bioactive molecules (docking studies). Pharmacophore analysis. Homology Modelling.


  • Matsoukas, T. Tselios, V. Apostolopoulos. “Peptide analogues of Myelin Basic Protein epitopes in the treatment of Experimental Autoimmune Encephalomyelitis (EAE) and Multiple Sclerosis (MS)”. GPO AGIK 38/17, CO7K 14/47, 09/05/2002/USA.
  • Matsoukas, T. Tselios et al. “Peptide Analogues and Conjugates Thereof”: PCT/IB2008/003493, WO 2009/066175, (28.05.2009), European No. 08851987.1 / 1402/2227486 (Granted). Short Description: “MBP analogues conjugated with mannan using KLH bridge”.
  • Tselios et al. “Immunotherapy of Multiple Sclerosis Using Mannosylated Peptides as Therapeutic Vaccines”: PCT/IB2009/000382, WO 2009/093143 (30.07.2009). Greece (ΟΒΙ) Νο. 1006998/30.09.2010 (Granted). European No. 09703874.9 / 1412/2240200 (Granted); Short Description: “MBP analogues conjugated with mannan via KGn bridge”. Divisional No. 14156495.5 (Granted); Short Description: “MOG analogues conjugated with mannan via KGn bridge”. Australia No. 2009207345 (Granted); Short Description: “MOG analogues conjugated with mannan via KGn bridge”. Divisional No. 2014200921 (Granted); Short Description: “MBP analogues conjugated with mannan via KGn bridge”. USA No. 12/864,019 (Granted); Short Title: “Conjugates comprising mannan and myelin oligodentrocyte glycoprotein (MOG)”; Short Description: “MOG analogues conjugated with mannan via KGn bridge”. Divisional: No. 14/877,679 (Granted); Short Title: “Conjugates comprising mannan and myelin basic protein (MBP)”; Short Description: “MBP analogues conjugated with mannan via KGn bridge”.

Representative Publications

  • E.D. Mantzourani, T. Tselios*, S. Golič Grdadolnik, J.A. Platts, A. Brancale, G. Deraos, J.M. Matsoukas, T.M. Mavromoustakos*. Comparison of Proposed Putative Active Conformations of Linear Altered Peptide Ligands of Myelin Basic Protein Epitope 87-99 by Spectroscopic and Modelling studies: The Role of Position 91 and 96 in T-cell Receptor Activation. J. Med. Chem., 2006, 49, 6683-6691.
  • Spyranti, G.A. Dalkas, G.A. Spyroulias*, E.D. Mantzourani, T. Mavromoustakos, I. Friligou, J.M. Matsoukas, Tselios T.V.*. Putative Bioactive Conformations of Amide Linked Cyclic Myelin Basic Protein Peptide Analogues Associated with Experimental Autoimmune Encephalomyelitis. J. Med. Chem., 2007, 29, 50(24): 6039-6047.
  • T. Matsoukas, P. Zoumpoulakis, T. Tselios*. Conformational analysis of aliskiren, a potent renin inhibitor, using high-resolution nuclear magnetic resonance and molecular dynamics simulations. J. Chem. Inf. Model., 2011, 26;51(9): 2386-2397.
  • Taoufik, V. Tseveleki, S.Y. Chu, T. Tselios, M. Karin, H. Lassmann, DE. Szymkowski, L. Probert*. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain, 2011, 134(9): 2722-2735.
  • Laimou, T. Katsila, J. Matsoukas, A. Schally, K. Gkountelias, G. Liapakis, C. Tamvakopoulos, T. Tselios*. Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties. Eur. J. Med. Chem., 2012, 58: 237-247.
  • T. Matsoukas, A. Cordomí, S. Ríos, L. Pardo, T. Tselios*. Ligand binding determinants for angiotensin II type 1 receptor from computer simulations. J. Chem. Inf. Model., 2013, 25, 53(11): 2874-2883..
  • Tseveleki, T. Tselios*, I. Kanistras, O. Koutsoni, M. Karamita, S.S. Vamvakas, V. Apostolopoulos, E. Dotsika, J. Matsoukas, H. Lassmann, L. Probert*. Immunotherapy of autoimmune encephalomyelitis using mannan-conjugated peptides to target antigen-presenting cells: A pre-clinical study in mice. Exp. Neurol., 2015, 267: 254-267.
  • P. Yannakakis, C. Simal, H. Tzoupis, M. Rodi, N. Dargahi, M. Prakash, A. Mouzaki, J.A. Platts, V. Apostolopoulos*, T.V. Tselios*. Design and Synthesis of Non-Peptide Mimetics Mapping the Immunodominant Myelin Basic Protein (MBP83-96) Epitope to Function as T-Cell Receptor Antagonists. Int. J. Mol. Sci., 2017, 18(6), pii: E1215. doi: 10.3390/ijms18061215.
  • G. Kordopati, H. Tzoupis, A.N. Troganis, G.M. Tsivgoulis, S. Golic Grdadolnik, C. Simal, T.V. Tselios*. Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics. J. Comput. Aided Mol. Des., 2017, 31(9): 841-854.
  • Tapeinou, E. Giannopoulou, C. Simal, B.E. Hansen, H. Kalofonos, V. Apostolopoulos, A. Vlamis-Gardikas, T. Tselios*. Design, synthesis and evaluation of an anthraquinone derivative conjugated to myelin basic protein immunodominant (MBP85-99) epitope: Towards selective immunosuppression. Eur. J. Med. Chem., 2018, 143: 621-631.

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