Vlamis Alexios

Vlamis A.
Vlamis A.

Assistant Professor

Tel: (+302610) 997634

Fax: (+302610) 997118


Web Page: http://www.chem.upatras.gr/faculty/vlamis

Curriculum Vitae

After obtaining a degree in Biology (ptychion, University of Athens), A. Vlamis, went to UK for an M.Sc in Clinical Biochemistry (University of Newcastle-upon-Tyne) and a Ph.D. in biochemistry (University of Sussex). He then moved to Sweden (1994 to 2003) where he worked at the Department of Biochemistry at the Karolinska Institute (associate professor in 2003). In 2004 he returned to Greece where he worked at the Institute for Biomedical Research of the Academy of Athens. In June 2009 he was elected assistant professor of biochemistry and molecular biology at the Department of Chemistry, University of Patras, in which he has been working since May 2011.



Research Activities

His main scientific interests lie within the field of electron flow via the thiol systems of thioredoxins and glutaredoxins. He has experience in the mechanisms that regulate the redox environment of cells (glutathione, glutaredoxins, and signal transduction pathways), oxidative stress, protein interactions in redox pairs. Other areas of knowledge include the overexpression of eukaryotic and prokaryotic proteins and their purification and characterization.

Representative Publications

  • Vlamis-Gardikas, A., Åslund, F., Spyrou, G., Bergman, T., and Holmgren, A. (1997).
    Cloning overexpression and characterisation of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli.
    J. Biol. Chem. 272, 11236-11243
  • Lillig, C. H., Prior, A., Schwenn, J. D., Åslund, F., Ritz, D., Vlamis-Gardikas, A., and Holmgren, A. (1999).
    New thioredoxins and glutaredoxins as electron donors of 3'-phosphoadenylylsulfate reductase.
    J. Biol. Chem. 274, 7695-7698
  • Shi, J., Vlamis-Gardikas, A., Åslund, F., Holmgren, A., and Rosen, B. P. (1999).
    Reactivity of glutaredoxins 1, 2 and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalysed arsenate reduction.
    J. Biol. Chem. 274, 36039-36042
  • Daily, D., Vlamis-Gardikas, A., Offen, D., Mittelman, L., Melamed, E., Holmgren, A., and Barzilai, A. (2001)
    Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the Ras-phosphoinositide 3 kinase and Jun N-terminal kinase pathways.
    J. Biol. Chem. 276, 21618-26
  • Xia, B,. Vlamis-Gardikas A., Holmgren, A., Wright, P. E., and Dyson H. J. (2001)
    Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases.
    J. Mol. Biol. 310, 907-18
  • Potamitou A, Holmgren A, Vlamis-Gardikas A. (2002)
    Protein levels of Escherichia coli thioredoxins and glutaredoxins and their realtion to null mutants, growth phase and function.
    J Biol Chem. 277, 18561-67
  • Vlamis-Gardikas, A., and Holmgren, A. (2002)
    Thioredoxin and glutaredoxin isoforms.
    Method Enzymol 347, 286-96
  • Singha, N. C., Vlamis-Gardikas, A., Holmgren, A.
    Real-time kinetics of the interaction between the two subunits, Eschericia coli thioredoxin and gene 5 protein of phage T7 DNA polymerase.
    (2003) J Biol Chem., 278, 21421–21428
  • Potamitou Fernandes A., Fladvad, M., Berndt, C., Lillig, C. H., Neubauer, P., Sunnerhagen, M., Holmgren, A., and Vlamis-Gardikas, A. (2005)
    A novel monothiol glutaredoxin (Grx4) from Escherichia coli, can serve as a substrate for thioredoxin reductase.
    J. Biol. Chem. 280, 24544-52
  • Vlamis-Gardikas A.
    The multiple functions of the thiol-based electron flow pathways of Escherichia coli: Eternal concepts revisited.
    Biochim Biophys Acta (2008) 1780, 1170-200.

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