Poulos Constantine

poulos
poulos

Professor Emeritus

Tel: (+302610) 997172
Fax: (+302610) 997172
e-mail:
Web Page: http://www.chem.upatras.gr/faculty/poulos

Curriculum Vitae

Constantine Poulos was born in Athens at 1947. In 1970 graduated in Chemistry from the National Kapodistrian University of Athens. In 1972 started his postgraduate studies in the Department of Chemistry at the University of Manchester Institute of Science and Technology and at 1976 the Ph.D degree was awarded to him by the University of Manchester. In 1977 started his academic career in the Laboratory of Organic Chemistry at the University of Patras and since 1996 he has been full Professor in Organic Chemistry in the Department of Chemistry at the University of Patras. He has been Director of Organic Chemistry, Biochemistry and Natural Products Division in the Department of Chemistry, Head of the Department of Chemistry (2001-2005) and since 2000 has been Director of the Laboratory for the Interdisciplinary Design of Science Teaching in the School of Science in the University of Patras. He is a Member of the Association of Greek Chemists and Member of the Royal Society of Chemistry (Chartered Chemist, Fellow of the Royal Society of Chemistry).


Courses

· Introduction to Organic Chemistry / Mechanisms in Organic Chemistry
· Experimental Organic Chemistry II
· Industrial Organic Products
· Special modules in Organic and Bioorganic Chemistry in Postgraduate Programmes of the Department of Chemistry/University of Patras.
In all the above modules Green Chemistry has been infused.


Research Activities

·Design and synthesis of analogues of biologically active peptides ( mammalian tachykinis, insect neuropeptides) and structure activity studies. The aims of the above research are a) the development of non-opiod drugs for pain relief and b) the development of environmentally friendly insecticides for a sustainable agriculture.
· Isolation and characterization of natural products from plants.
In the above research activities Constantine Poulos had a close and fruitful collaboration with Professor R.Ramage, Head of Chemistry Departments at the University of Manchester Institute of Science and Technology and at the University of Edinburgh, the Neuropharmacology Department of Glaxo/U.K., Dr. Paolo Rovero (Intituto di Mutagenesi & Differenziamento, Pisa, Italy), Dr.C.A.Maggi (A.Menarini Pharmaceuticals, Pharmacology Dept., Florence, Italy), Professor of Biology Graham Goldsworthy (Birkbeck College, University of London), Professor Arnold De Loof (Zoological Institute of Katholieke Universiteit of Leuven, Belgium) and Dr. V.Dourtoglou (Vioryl S.A., Athens).


Publications

  • Mathematical modelling of insect neuropeptide potencies. Are quantitatively predictide models possible?
    M. J. Lee, S. de Jong, G. Gade, C. Poulos and G. J. Goldsworthy Insect Biochemistry and Molecular Biology 30, 899-907 (2000).
  • W. Zhu, A. Vandingenen, R. Huybrechts, G. Baggerman, A. De Loof, C.P. Poulos, A. Velentza and M. Breuer.
    Insect Biochemistry and Molecular Biology 31:87-95 (2001).
  • Pyrokinin neuropeptides in a crustacean: Isolation and identification in the white shrimp Penaeus vannamei.
    P. Torfs, J. Nieto, A. Certiaens, D.Boon, G. Baggerman, C.Poulos, E. Waelkens, R. Derua, J. Calderon, A. De loof and L.
    Schoofs Eur. J. Biochem. 268, 149-154 (2001).
  • Quick regiospecific analysis of fatty acids in triacylglycerols with GC using 1,3-specific lipase in butanol.
    T. Dourtoglou, E. Stefanou, S. Lalas, V. Dourtoglou and C.Poulos
    Analyst 126, 1032-1036 (2001).
  • Proteolytic break down of the Neb-trypsin modulating oostatic factor (Neb-TMOF) in the hemolymph of different insevts and its gut epithelial transport.
    W. Zhu, A. Vandingenen, R. Huybrechts, T. Vercammen, G. Baggerman , A. De Loof, C.P. Poulos, A. Velentza and M. Breuer.
    Journal of Insect Physiology 47, 1235-1242 (2001).
  • New insights in Adipokinetic Hormone (AKH) precursor processing in locusta migratoria obtained by capillary liquid chromatography-tadem mass spectroscopy.
    G. Baggerman, J. Huybrechts, K. Hens, L. Harthoom, D. Van der Hors, C.Poulos, A. De loof and L. Schoofs
    Peptides 23, 635-644 (2002).
  • Activity of crustacean myotropic neuropeptdes on the oviduct and hindgut of the crayfish Astacus leptodactylus.
    P.Torfs, R.J.Nachman, C.Poulos, A. De Loof and L. Schoofs
    Invertebrate Reproduction & Development 41(1-3), 137-142 (2002).
  • Structural elucidation and conformational properties of the toxin paralysin β-Ala-Tyr.
    I.Kyrikou, S.G. Grdadolnik, M.Tatari, C.Poulos and Th.Mavromoustakos.
    Journal of Pharmaceutical and Biomedical Analysis 31(4), 713-721 (2003).
  • Detection of olive oil adulteration using principal component analysis applied on total and region FA content.
    V.G. Dourtoglou, Th. Dourtoglou, A. Antonopoulos, E. Stefanou, S. Lalas and C.Poulos,
    Journal of the American oil Chemist's Society, 23(4), 635-644 (2003).
  • The synthesis of an analogue of the locust CRF-like diuretic peptide and the biological activities of this and some C-terminal fragments.
    G.J.Goldsworthy, J.S. Chung, M.S.J. Simmonds, M. Tatari, S. Varouni and C.P. Poulos,
    Peptides, 24(10), 1607-1613 (2003).