Skandalis S. Spyridon


Assistant Professor

Tel: (+302610) 997913

Fax: (+302610) 997118


Web Page:

Curriculum Vitae

Assistant Professor of Biochemistry, Department of Chemistry, University of Patras

Education & Degrees

2000: B. Sc., Department of Chemistry, University of Patras, Greece

2003: Ph. D., Major: Biochemistry, Molecular Biology. Department of Chemistry, University of Patras

2003: Visiting Graduate Student, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden

2005-2006: Postdoctoral Fellow, Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Center for Scientific Research “Demokritos”, Athens, Greece

2006-2010: Postdoctoral Researcher, Matrix Biology Group, Ludwig Institute for Cancer Research, Uppsala University, Sweden

2012-2014: Postdoctoral Researcher, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece

2014-2016: Lecturer, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece

2016-present: Assistant Professor, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece


2000-2001: Fellowship for Graduate Students by the General Secretariat for Research and Technology (tenure: 18 months)

2002-2003: Fellowship for Graduate Students by the Institute of Chemical Engineering and High Temperature Chemical Processes (FORTH/ICE-HT) (tenure: 12 months)

2003: FEBS (Federation of European Biochemical Societies) Short-Term Fellowship for Graduate Students (tenure: 3 months)

2005-2006: Postdoctoral Fellowship by the Greek State Scholarship’s Foundation (IKY) (tenure: 18 months)

2006: FEBS (Federation of European Biochemical Societies) Short-Term Postdoctoral Fellowship (tenure: 3 months)

2007-2008: Postdoctoral Fellowship by the WENNER-GREN FOUNDATIONS, Sweden (tenure: 24 months)

2009-2010: Postdoctoral Fellowship by the Ludwig Institute for Cancer Research Ltd (tenure: 18 months)

Guest Editor/Editorial Board member

  • Special Issue (Lead Guest Editor: Spyros Skandalis; Guest Editors: Katalin Dobra, Martin Gotte, Eugenia Karousou, Suniti Misra): Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease, Biomed Research International ( (2015).
  • Member of the Editorial Board of Biochemistry Research International (

Organization of National/International Conferences, Courses, Meetings/Symposia

  • Member of the Organizing Committee of the 2nd Matrix Biology Europe Conference ( (Athens, June 11-14, 2016).
  • Member of the Organizing Committee of the 6th FEBS Advanced Lecture Course on Matrix Pathobiology, Signaling and Molecular Targets ( (Spetses, May 25-30, 2017).


Front Cover of Biochimie (2006), Best Oral Presentation Award (FEBS-MPST 2009) (2009), FEBS Journal Top-Cited Paper Award (2010), Best Poster Award (FEBS-MPST 2011) (2011), FEBS Journal Top-Cited Paper Award (2011), Best Poster Award (FEBS-MPST 2013) (2013), Best Oral Presentation Award (11th Meeting of Hellenic Society of Pharmacology) (2013), Most Downloaded Matrix Biology Article (2014)

Research Projects

Funded by MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) [Grant Agreement number: 645756 — GLYCANC — H2020-MSCA-RISE-2014] for the Action: "Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer". Collaborators: WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITA DEGLI STUDI DELL'INSUBRIA, UPPSALA UNIVERSITET, NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS", SEREND-IP GMBH, FIDIA FARMACEUTICI SPA, SEMMELWEIS EGYETEM, CAIRO UNIVERSITY.

Scientific Organization Membership

  • Hellenic Society for Biochemistry & Molecular Biology (HSBMB) (FEBS Constituent Society)
  • Matrix Biology Section of HSBMB
  • International Society of Hyaluronan Sciences (ISHAS)
  • International Society for Matrix Biology (ISMB)

Publications/Book Chapters/Conferences/Recognition

  • 44 publications in peer-review International Journals; 28 original Research articles and 16 Reviews (7 as Corresponding Author, 28 as First/Second Author)
  • 3 Book Chapters (2 as First Author)
  • More than 90 abstracts in Proceedings of International and Hellenic Scientific Conferences
  • Reviewer of original articles/reviews for a number of International Scientific Journals (The Journal of Biological Chemistry, PLoS ONE, BBA-General Subjects, BBA-Molecular and Cell Biology of Lipids, FEBS Journal, FEBS Letters, Journal of Cellular Physiology, International Journal of Cancer, Respiratory Research, Journal of Cellular Biochemistry, Biochemistry Research International, Molecular and Cellular Therapeutics, Food and Chemical Toxicology)
  • Cited more than 1300 times
  • H-index is 20 (January 2017) (sources: Scopus, WoS, Scholar Google)


Supervisor for 1 Ph. D. and 2 M. Sc. Students (January 2017).


UnderGraduate Teaching

  1. Biochemistry-2 (Theoretical Courses & Laboratory)
  2. Biochemistry-3 (Theoretical Courses & Laboratory)

iii) Biotechnology (Theoretical Courses & Laboratory)

PostGraduate Teaching: Courses Masters & Ph.D.

  1. Advanced Biochemistry I (Lectures) (in M. Sc./Ph. D. Program of Dept. of Chemistry: Applied Biochemistry Clinical Chemistry, Biotechnology and Evaluation of Pharmaceutical Products)
  2. Organic Chemistry of Biological Pathways (Lectures) (in Interdepartmental (Depts of Chemistry-Medicine-Pharmacy) M. Sc. Program: Chemical Biology)
  3. Chemical Biology (Lectures) (in Interdepartmental (Depts of Chemistry-Medicine-Pharmacy) M. Sc. Program: Chemical Biology)


Research Interests (Extracellular matrix pathobiology, cell-matrix interactions, cell signaling, tumor microenvironment, molecular targeting)

The role and impact of ExtraCellular Matrices (ECMs) on cell behavior are my main research interests. Special emphasis is given on Proteoglycans, Glycosaminoglycans, Metalloproteinases (MMPs), Growth Factors/Growth Factor Receptors as well as their cross-talk, and especially their implication in normal tissue homeostasis and the onset and progression of cancer. The methods utilized in our lab range from traditional to modern biochemistry and molecular/cell biology techniques as well as from tissue to cell level.

Among others, my studies are focused on:

  1. Biochemical studies of matrix effectors (such as Hyaluronan, Proteoglycans, MMPs) as well as specific cell surface receptors (such as CD44);
  2. Investigation of the interactions of matrix effectors with cell surface receptors and their impact on intracellular signaling pathways and cell functional properties;
  3. Gene suppression or overexpression of specific effectors in order to identify novel molecular targets for cancer treatment;
  4. Synthesis and biological applications of Heparan Sulfate/Heparin-like polymers (in collaboration with Polymer Science Group). 


  • Afratis NA, Bouris P, Skandalis SS, Multhaupt HA, Couchman JR, Theocharis AD, Karamanos NK. IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules. Sci Rep. (2017)
  • Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS. Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol. (2016)
  • Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Adv Drug Deliv Rev. (2016)
  • Skandalis SS, Dobra K, Götte M, Karousou E, Misra S. Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease. Biomed Res Int. (2015)
  • Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta – Reviews in Cancer (2015)
  • Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK. Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells. Matrix Biol. (2015)
  • Skandalis SS, Gialeli C, Theocharis AD, Karamanos NK. Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer. Adv Cancer Res. (2014)
  • Skandalis SS, Afratis N, Smirlaki G, Nikitovic D, Theocharis AD, Tzanakakis GN, Karamanos NK. Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans. Matrix Biol. (2014)
  • Korpetinou A, Skandalis SS, Moustakas A, Happonen KE, Tveit H, Prydz K, Labropoulou VT, Giannopoulou E, Kalofonos HP, Blom AM, Karamanos NK, Theocharis AD. Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells. PLoS One. (2013)
  • Syggelos SA, Aletras AJ, Smirlaki I, Skandalis SS. Extracellular matrix degradation and tissue remodeling in periprosthetic loosening and osteolysis: focus on matrix metalloproteinases, their endogenous tissue inhibitors, and the proteasome. Biomed Res Int. (2013)