Skandalis S. Spyridon

skandalis
skandalis

Assistant Professor

Tel: (+302610) 997913

Fax: (+302610) 997118

e-mail:

Web Page: http://www.chem.upatras.gr/faculty/skandalis

Curriculum Vitae

Assistant Professor of Biochemistry, Department of Chemistry, University of Patras

Education & Degrees

2000: B. Sc., Department of Chemistry, University of Patras, Greece

2003: Ph. D., Major: Biochemistry, Molecular Biology. Department of Chemistry, University of Patras

2003: Visiting Graduate Student, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden

2005-2006: Postdoctoral Fellow, Laboratory of Cell Proliferation and Ageing, Institute of Biology, National Center for Scientific Research “Demokritos”, Athens, Greece

2006-2010: Postdoctoral Researcher, Matrix Biology Group, Ludwig Institute for Cancer Research, Uppsala University, Sweden

2012-2014: Postdoctoral Researcher, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece

2014-2016: Lecturer, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece

2016-present: Assistant Professor, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Greece

Distinctions

2000-2001: Fellowship for Graduate Students by the General Secretariat for Research and Technology (tenure: 18 months)

2002-2003: Fellowship for Graduate Students by the Institute of Chemical Engineering and High Temperature Chemical Processes (FORTH/ICE-HT) (tenure: 12 months)

2003: FEBS (Federation of European Biochemical Societies) Short-Term Fellowship for Graduate Students (tenure: 3 months)

2005-2006: Postdoctoral Fellowship by the Greek State Scholarship’s Foundation (IKY) (tenure: 18 months)

2006: FEBS (Federation of European Biochemical Societies) Short-Term Postdoctoral Fellowship (tenure: 3 months)

2007-2008: Postdoctoral Fellowship by the WENNER-GREN FOUNDATIONS, Sweden (tenure: 24 months)

2009-2010: Postdoctoral Fellowship by the Ludwig Institute for Cancer Research Ltd (tenure: 18 months)

Guest Editor/Editorial Board member

  • Special Issue (Lead Guest Editor: Spyros Skandalis; Guest Editors: Katalin Dobra, Martin Gotte, Eugenia Karousou, Suniti Misra): Impact of Extracellular Matrix on Cellular Behavior: A Source of Molecular Targets in Disease, Biomed Research International (2015).
  • Member of the Editorial Board of Cellular Signalling
  • Member of the Editorial Board (Topic Editor) of International Journal of Molecular Sciences
  • Member of the Editorial Board of Biochemistry Research International

Organization of National/International Conferences, Courses, Meetings/Symposia

Research Projects

- Collaborator in MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) [Grant Agreement number: 645756 — GLYCANC — H2020-MSCA-RISE-2014] for the Action: "Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer". Collaborators: WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER, UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITA DEGLI STUDI DELL'INSUBRIA, UPPSALA UNIVERSITET, NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS", SEREND-IP GMBH, FIDIA FARMACEUTICI SPA, SEMMELWEIS EGYETEM, CAIRO UNIVERSITY [2015-2019].

- Principal Investigator for the Grant (project code: 80626) from the Research Committee of the University of Patras, Greece, via “C. CARATHEODORI” program [2019-2022].

Scientific Organization Membership

  • Hellenic Society for Biochemistry & Molecular Biology (HSBMB) (FEBS Constituent Society)
  • Matrix Biology Section of HSBMB
  • International Society of Hyaluronan Sciences (ISHAS)
  • International Society for Matrix Biology (ISMB)

Publications/Book Chapters/Conferences/Recognition

  • 48 publications in peer-review International Journals; 30 original Research articles and 18 Reviews (10 as Corresponding Author, 30 as First/Second Author)
  • 3 Book Chapters (2 as First Author)
  • More than 100 abstracts in Proceedings of International and Hellenic Scientific Conferences
  • Reviewer of original articles/reviews for a number of International Scientific Journals (Nature Communications, Advanced Drug Delivery Reviews, Matrix Biology, The Journal of Biological Chemistry, PLoS One, BBA-General Subjects, BBA-Molecular and Cell Biology of Lipids, FEBS Journal, FEBS Letters, Cellular Signalling, Journal of Cellular Physiology, International Journal of Cancer, Respiratory Research, Journal of Cellular Biochemistry, Biochemistry Research International, Molecular and Cellular Therapeutics, Food and Chemical Toxicology, Cellular & Molecular Biology Letters)
  • Cited more than 2.500 times (December 2019) (sources: Scopus, WoS, Scholar Google)
  • H-index is 25 (December 2019) (sources: Scopus, WoS, Scholar Google)

Invited Lectures

  • Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, United Kingdom, 2009, entitled: Novel CD44 Interacting Proteins: the CD44-iASPP-p53 axis.
  • 3rd FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Spetses, Greece, 2011, entitled: Proteomic Identification of CD44 Interacting Proteins: the CD44-iASPP-p53 axis.
  • 6th FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Spetses, Greece, 2017, entitled: An introduction to ECM dynamic network - Proteoglycans.
  • FEBS Advanced Lecture Course: Cell Regulation, Epigenetics and Modeling Patras, Greece, 2018, entitled: Proteoglycans: Structure and neofunctions.
  • 7th FEBS Advanced Lecture Course: Matrix Pathobiology, Signaling & Molecular Targets, Porto Heli, Greece, 2019, entitled: Repression of oncogenic hyaluronan biosynthesis in breast cancer
  • Uppsala University, IMBIM Tumor Biology Seminar, Uppsala, Sweden, 2019, entitled: Suppression of the oncogenic hyaluronan network in breast cancer
  • 70th National Conference of the Hellenic Society of Biochemistry and Molecular Biology, Athens, Greece, 2019, entitled: Targeting of the oncogenic extracellular matrix network in breast cancer

Trainees

- Supervisor for 2 Ph.D., 3 M.Sc.  and a number of undergraduate Students (December 2019).

- Member of the Examination Committee for a number (>20) of Ph.D. & M.Sc. Students of Postgraduate Programs at the Departments of Chemistry, Medicine, Pharmacy of the University of Patras.


Courses

Undergraduate Teaching

  1. Biochemistry-2 (Theoretical Courses & Laboratory)
  2. Biochemistry-3 (Theoretical Courses & Laboratory)
  3. Biotechnology (Theoretical Courses & Laboratory)

Postgraduate Teaching: Courses Masters & Ph.D.

  1. Advanced Biochemistry (Lectures) (in Interinstitutional M.Sc. Program of Dept. of Chemistry, University of Patras with the National Center for Scientific Research “Demokritos”: Applied Biochemistry Clinical Chemistry, Biotechnology and Evaluation of Pharmaceutical Products)
  2. Organic Chemistry of Biological Pathways (Lectures) (in Interdepartmental (Depts of Chemistry-Medicine) M.Sc. Program: Medicinal Chemistry & Chemical Biology)
  3. Chemical Biology (Lectures) (in Interdepartmental (Depts of Chemistry-Medicine) M.Sc. Program: Medicinal Chemistry & Chemical Biology) – Coordinator
  4. The Macromolecules as Targets of Therapeutic Approaches (Lectures) (in Interdepartmental (Depts of Chemistry-Medicine) M.Sc. Program: Medicinal Chemistry & Chemical Biology) – Coordinator

Research Interests

Key words: Extracellular matrix pathobiology, hyaluronan, CD44, cell-matrix interactions, tumor microenvironment, molecular targeting

The role and impact of ExtraCellular Matrices (ECMs) on cell behavior are my main research interests. Special emphasis is given on Proteoglycans, Glycosaminoglycans, Metalloproteinases (MMPs), Growth Factors/Growth Factor Receptors as well as their cross-talk, and especially their implication in normal tissue homeostasis and the onset and progression of cancer. The methods utilized in our lab range from traditional to modern biochemistry and molecular/cell biology techniques as well as from tissue to cell level.

Among others, my studies are focused on:

  1. Biochemical studies of matrix effectors (such as Hyaluronan, Proteoglycans, MMPs) as well as specific cell surface receptors (such as CD44);
  2. Investigation of the interactions of matrix effectors with cell surface receptors and their impact on intracellular signaling pathways and cell functional properties;
  3. Pharmacological targeting of specific matrix effectors (i.e. Hyaluronan) in order to identify novel molecular targets for (breast) cancer treatment (in collaboration with Uppsala University);
  4. Synthesis and biological applications of Heparan Sulfate/Heparin-like polymers (in collaboration with Polymer Science Group); 
  5. Application and evaluation of Cold Atmospheric Plasma technology on tumor cells (in collaboration with ICE-HT)

Publications

  • Skandalis SS*, Karalis TT, Chatzopoulos A, Karamanos NK. Hyaluronan-CD44 axis orchestrates cancer stem cell functions. Cell Signal. (2019)
  • Skandalis SS*, Karalis TT, Heldin P. Intracellular hyaluronan: Importance for cellular functions. Semin Cancer Biol. (2019)
  • Heldin P, Lin CY, Kolliopoulos C, Chen YH, Skandalis SS. Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production. Matrix Biol. (2019)
  • Karalis TT, Heldin P, Vynios DH, Neill T, Buraschi S, Iozzo RV, Karamanos NK, Skandalis SS*. Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors. Matrix Biol. (2019)
  • Karousou E, Misra S, Ghatak S, Dobra K, Götte M, Vigetti D, Passi A, Karamanos NK, Skandalis SS*. Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol. (2017)
  • Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Adv Drug Deliv Rev. (2016)
  • Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, Gopal S, Gomes A, Afratis N, Lim HC, Couchman JR, Filmus J, Sanderson RD, Schaefer L, Iozzo RV, Karamanos NK. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta – Reviews in Cancer (2015)
  • Bouris P, Skandalis SS, Piperigkou Z, Afratis N, Karamanou K, Aletras AJ, Moustakas A, Theocharis AD, Karamanos NK. Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells. Matrix Biol. (2015)
  • Skandalis SS, Gialeli C, Theocharis AD, Karamanos NK. Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer. Adv Cancer Res. (2014)
  • Skandalis SS, Afratis N, Smirlaki G, Nikitovic D, Theocharis AD, Tzanakakis GN, Karamanos NK. Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of proteoglycans. Matrix Biol. (2014)