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Papaioannou Dionysios


Professor Emeritus

Tel: (+302610) 962954

Fax: (+302610) 962956

e-mail: ,

Web Page:

List of publications:

Contact hours: Monday, Wednesday and Friday 12:00-14:00

Curriculum Vitae

Dionissios Papaioannou was born in Patras, Greece, in 1952. He studied chemistry at the University of Patras from where he was graduated in 1974. He carried out postgraduate studies at Imperial College of Science and Technology (Chemistry Department) in London and completed (1977) his PhD thesis on "Syntheses using isonitriles"; under the supervision of Prof. D.H.R. Barton. In 1980 he joined the faculty of the Chemistry Department of the University of Patras as a lecturer. Since 1996 he is professor of Organic Chemistry. He has conducted postdoctoral work at the Chemistry Department at Imperial College and the University of Bergen, Norway.


1) Structure, Reactivity and Mechanism in Organic Chemistry (Chem. Dept., UoP)
2) Synthetic Organic Chemistry (Chem. Dept. and Inter-departmental ΜSc Programme “CHEMICAL BIOLOGY, UoP)
3) Synthetic Inorganic, Organic and Organometallic Chemistry (MSc Programme ‘’Synthetic Chemistry and Advanced Polymeric and Nanostructured Materials’’; Chem. Dept., UoP)
4) Advanced Synthetic Organic Chemistry (Inter-departmental ΜSc Programme “CHEMICAL BIOLOGY, UoP)

Research Activities

Prof. Papaioannou' s main research activities have been focused on the:
1) development of methodologies for the efficient synthesis of amino acid derivatives and peptides,
2) asymmetric synthesis of biologically interesting amino acids and dideoxynucleosides using suitable proteinogenic or other naturally occurring amino acids as chiral templates, and
3) synthesis of alkaloids, terpenyl polyols and aminopolyols, and polyamines and conjugates thereof with a variety of biologically interesting other molecules.

Recently, his research interests are focused in the area of synthesis of:

1) compounds with a dermatological interest (derivatives of retinoids, psoralens, dithranol, minoxidil etc) aiming to the modification/improvement of their pharmaceutical activity,
2) compounds with antimicrobial (chloraphenicol derivatives) or antidiabetic (peptide mimetics) interest,
3) lignans with pharmaceutical interest, and
4) modified fullerenes for drug delivery.


  • Μ. Militsopoulou, S. Ε. Bariamis, C. M. Athanassopoulos and Papaioannou
    Synthetic Studies towards the Development of Psoralen-Acidic Retinoid Conjugates and Hybrids”
    Synthesis, 2008, 3433-3442.
  • Magoulas, D. Papaioannou, E. Papadimou, D. Drainas
    “Preparation of Spermine Conjugates with Acidic Retinoids with Potent Ribonuclease P Inhibitory Activity”
    European Journal of Medicinal Chemistry, 2009, 44, 2689-2695.
  • E. Magoulas, S. E. Bariamis, C. A, Athanassopoulos, A. Haskopoulos, P. C. Dedes, P. G. Krokidis, N. K. Karamanos, D. Kletsas, D. Papaioannou, G. Maroulis
    “Synthesis, Antiproliferative Activity and Theoretical Characterization of Acidic-type Retinoids with Changes in the Lipophilic Part”
    European Journal of Medicinal Chemistry, 2011, 46, 721-737.
  • E. Magoulas, T. Garnelis, C.M. Athanassopoulos, D. Papaioannou, G. Mattheolabakis, K. Avgoustakis, D. Hadjipavlou-Litina
    “Synthesis and Antioxidative/Anti-inflammatory Activity of Novel Fullerene-Polyamine Conjugates”
    Tetrahedron, 2012, 68, 7041-7049.
  • Hadjipavlou-Litina, G. E. Magoulas, S. E. Bariamis, Z. Tsimali, K. Avgoustakis, C. A. Kontogiorgis, C. A. Athanassopoulos, D. Papaioannou
    “Synthesis and Evaluation of the Antioxidant Potential of Minoxidil-Polyamine Conjugates”
    Biochimie, 2013, 95, 1437-1449.
  • E. Magoulas, M. Bantzi, D. Messari, E. Voulgari, C. Gialeli, D. Barbouri, A. Giannis, N. K. Karamanos, D. Papaioannou, K. Avgoustakis
    ‘’Synthesis and Evaluation of Anticancer Activity in Cells of Novel Stoichiometric Pegylated Fullerene-Doxorubicin Conjugates’’.
    Pharmaceutical Research, 2014, DOI 10.1007/s11095-014-1566-1.
  • N. Kostopoulou, G. E. Magoulas, G. E. papadopoulos, A. Mouzaki, G. P. Dinos, D. Papaioannou, D. L. Kalpaxis
    ‘’Synthesis and Evaluation of Chloraphenicol Homodimers: Molecular Target, Antimicrobial Activity, and Toxicity against Human Cells’’.
    PLoS ONE, 2015, 10(8): e0134526. DOI 10.1371/journal.pone.0134526.
  • E. Bariamis, G. E. Magoulas, K. Grafanaki, E. Pontiki, T. Tsegenidis, C. M. Athanassopoulos, G. Maroulis, D. Papaioannou and D. Hadjipavlou-Litina
    “Synthesis and Biological Evaluation of New C-10 Substituted Dithranol Pleiotropic Hybrids”
    Bioorganic & Medicinal Chemistry, 2015, 23, 7251-7263.
  • E. Magoulas, A. Rigopoulos, Z. Piperigkou, C. Gialeli, N. K. Karamanos, P. G. Takis, A. N. Troganis, A. Chrissanthopoulos, G. Maroulis and D. Papaioannou
    “Synthesis and Antiproliferative Activity of Two Diastereomeric Lignan Amides Serving as Dimeric Caffeic Acid-L-Dopa Hybrids”
    Bioorganic Chemistry, 2016, 66, 132-144.
  • E. Magoulas, T. Tsigkou, L. Skondra, M. Lamprou, P. Tsoukala, V. Kokkinogouli, E. Pantazaka, D. Papaioannou, C. M. Athanassopoulos, E. Papadimitriou
    “Synthesis of Novel Artemisinin Dimers with Polyamine Linkers and Evaluation  of their Potential as Anticancer Agents”
    Bioorganic & Medicinal Chemistry, 2017, 25, 3756-3767.

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