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4th FEBS Advanced Lecture Course (FEBS-MPST 2013)

Matrix Pathobiology, Signaling and Molecular Targets

26th September – 1st October 2013, Kos Island, Greece

Organizing Committee: N. Karamanos, R. Iozzo, D. Heinegård, V. Hascall,  D. Kletsas, A. Theocharis, Ch. Gialeli

www.febs-mpst2013.upatras.gr

Based on the advances occurred during the last years in matrix organization and matrix-mediated regulation of the various cell functions, this 6-days advanced level  FEBS-MPST 2013 scientific meeting will offer oral sessions with invited plenary lectures and confirmed talks from outstanding experts, general lectures/tutorials, selected talks related to the topics of the presented abstracts, participant poster presentations, panel discussions and speakers’ corner. These sessions will address both basic and applied science topics that appeal to the range of participants working in the fields of matrix biology (pathobiochemistry and pathobiology), structural biology and cell and molecular biology.

Plenary Symposia will be introduced and moderated by leading scientists acting as discussion leaders. Symposia includes: Matrix Pathobiology / Interactions and Functions of Matrix Macromolecules / Glycobiology and Metabolic Regulation of ECM molecules / Matrix-mediated Signaling and EMT / Cell Receptors Signaling and ECM based Nanotechnology / Signaling and Disease Molecular Targeting / Matrix Regulation in Health and Disease.

The meeting will further cover topics related to ongoing development in the fields of:

  • Cell surface, interactions and signaling
  • Metalloproteinases and other proteases
  • Matrix organization and assembly
  • Cancer Stem Cell Biology and Biomarkers
  • Pharmacological Targeting

A number of FEBS Youth Travel Funds (FEBS YTF) for graduate students and postdoctoral researchers within five years of obtaining a PhD will be available, upon application, covering registration fees and expenses toward travelling. Talks will be selected from the submitted abstract. Young investigator awards will also available upon application.

The most important goal of the FEBS-MPST 2013 meeting is to bring together senior with young scientists from life sciences on an important and rapidly developing scientific field and to create the environment for a superb science, warm collegiality, and an all-around rewarding experience during this special time of year.

Deadlines for abstracts submissions and YTF applications:

May 20th, 2013: Deadline for FEBS YTF applications.

May 31st, 2013: Deadline for application/registration and abstract submission.

For further info, invited speakers/tutors, preliminary program, submission of abstracts, eligibility criteria for YTF applications and application/registration, visit the website: www.febs-mpst2013.upatras.gr, which is continuously updated.

We are looking forward to welcome you for an exciting and memorable scientific meeting.

Prof. Nikos Karamanos, Chairman

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­­­­­­­­­­­­­­­­­­­­­­­­­Invited Speakers & Confirmed Talks

  • Thomas N. Wight (USA) “Targeting Proteoglycans( Versican) in the Control of Inflammation in Cardiovascular Disease”
  • Renato Iozzo (USA) “ Proteoglycan, Cancer Biology, Tumor Angiogenesis”
  • Vincent Hascall (USA) “Hyaluronan in inflammatory pathologies”
  • John Couchman (Denmark) “Syndecans in cell adhesion, receptors and signaling”
  • Israel Vlodavski (Israel) “Heparanase: a valid target for drug development”
  • Dimitris Kletsas (Greece) “Cellular senescence and age-related pathologies, extracellular matrix, growth factors, signaling pathways, stress,  wound healing, cancer, biomaterials, stem cells and cell replacement therapy”
  • Jan-Olof Winberg (Norway) “Nature and properties of matrix metalloprotease-9/chondroitin sulphate proteoglycan complexes”
  • Liliana Schaefer (Germany) “Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation”
  • Donald Gullberg (Norway) “An overview of integrin structure and function”
  • Nikos Karamanos (Greece) “Matrix Molecular Targets in Breast Cancer, Proteoglycans, Metalloproteinases, ER crosstalk signaling pathways”
  • Paraskevi Heldin (Sweden) “Importance of microenvironment in tumor progression, Hyaluronan and HAS signaling, proteasome implication”
  • Jeffrey D. Esko (USA) “Proteoglycans, heparan sulfate, lysosomal storage, lipoprotein metabolism”
  • Dick Heinegård (Sweden) “Extracellular matrix molecules in tissue homeostasis and inflammation”
  • Alberto Passi (Italy) “Hyaluronan production in arteriosclerosis”
  • Carl-Henrik Heldin (Sweden) “Signaling via receptors for PDFGF and TGFbeta – possible targets in tumor therapy”
  • Dragana Nikitovic (Greece) “Tumor biology and ECM”
  • Lena Kjellen (Sweden) “Heparin biosynthesis; Heparan sulfate and embryonic development”
  • Kazuyuki Sugahara (Japan) “Sugar signals of proteoglycans in neurobiology and tumor biology”
  • David Birk (USA) "Regulatory roles of small leucine-rich proteoglycans in matrix assembly"
  • Achilleas Theocharis (Greece) “Proteoglycans (serglycin) in multiple myeloma and cancer progression”
  • Jorge Filmus (Canada) “Glypicans in development and cancer”
  • Veli-Matti Kähäri (Finland) “Proteolytic control of cutaneous wound repair and cancer progression“
  • Ralph Sanderson (USA) “Heparanase, syndecan and exosomes: A deadly combination that drives aggressive tumor behavior”
  • Themis R. Kyriakides (USA) “Extracellular matrix and vascular biology”
  • Peter Friedl (The Netherlands & USA) “Mechanisms of cancer invasion in vitro and in vivo: plasticity and limits“
  • Alan J. Grodzinsky (UK) “Matrix Molecular Nano-Mechanics and Mechanobiology: Relevance to Osteoarthritis and Cartilage Repair”
  • Boris Turk (Slovenia) “Cysteine cathepsins and their roles in inflammation-associated diseases”
  • Mauro Pavao (Brazil) “Effect of Heparin Analogs from Marine Invertebrates on Metastasis, Thrombus Formation and Inflammatory Bowel Disease”
  • Martin Götte (Germany) “Modulation of matrix- and cytokine-dependent signaling by Syndecan-1 affects breast cancer metastasis, stemness, and resistance to radiotherapy”
  • Antony Day (UK) “The role of ECM in immune regulation”
  • François Maquart (France) “Matrikines in the control of tumor invasion”
  • Muhammad Zaman (USA) “Integrated, quantitative systems level approaches to study migration and invasion in native environments”
  • Katalin Dobra (Sweden) “Signaling pathways regulated by syndecan-1 in malignant mesothelioma”
  • Efstathios S. Gonos (Greece) “Proteasome activation as a novel anti-aging strategy”
  • Paolo Bonaldo (Italy) "Collagen VI regulates muscle stem cell homeostasis and regeneration"
  • Joanna Phillips (USA) “Proteoglycans in the brain tumor microenvironment”
  • Steven Pals (Netherlands) “Heparan sulfate proteoglycans, stem cells and cancer”
  • Sarah Wilcox-Adelman (USA) “Syndesmos-a partner in syndecan-4 mediated cell migration”
  • Marco Maccarana (Sweden) “Biosynthesis and functions of dermatan sulfate”
  • Jerry Turnbull (UK) “Exploiting the heparan sulphate interactome: from biology to synthetic chemistry to therapeutic applications”
  • Demitrios Vynios (Greece) “ADAMTSs in cancer”
  • Ilona Kovalszky (Hungary) “Cancer associated fibroblast, the key player in matrix remodeling”
  • Johanna Ivaska (Finland) “Integrin activity and filopodia regulate invasion and matrix remodeling in cancer”
  • Li Jin-Ping (Sweden) “Implications of heparan sulfate in amyloidosis”